Thibaut De Smedt

TL;DR: It is reported here that both subclasses of DCs efficiently prime antigen-specific T cells in vivo, and direct the development of distinct T helper (Th) populations, and it is shown that interleukin 12 plays a critical role in Th1 development by CD8α+ DCs.

TL;DR: It is concluded that flt3L has an important role in the expansion of early hematopoietic progenitors and in the generation of mature peripheral leukocytes.

TL;DR: It is shown that TslP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor–deficient mice had considerably attenuated disease.

TL;DR: IL-1 blockade appears to be an effective therapy for acute gouty arthritis, according to a pilot, open-labeled study in patients with gout who could not tolerate or had failed standard antiinflammatory therapies.

TL;DR: The data show that DC that have undergone maturation in vitro in the presence of IL‐10, have an impaired capacity to induce a Th1‐type response in vivo, leading to the development of Th2 lymphocytes, and suggest thatIL‐10 skews the Th1/Th2 balance to Th2 in vivo by selectively blocking IL‐12 synthesis by the antigen‐presenting cells that play a role of adjuvant of the primary immune response.