T
Thilo Witsch
Researcher at University of Freiburg
Publications - 20
Citations - 593
Thilo Witsch is an academic researcher from University of Freiburg. The author has contributed to research in topics: Inflammation & Platelet activation. The author has an hindex of 9, co-authored 18 publications receiving 424 citations. Previous affiliations of Thilo Witsch include Boston Children's Hospital & Max Planck Society.
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Journal ArticleDOI
Neutrophil elastase‐deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis
Kimberly Martinod,Kimberly Martinod,Thilo Witsch,Thilo Witsch,Kalamo Farley,Kalamo Farley,Maureen Gallant,Eileen Remold-O'Donnell,Eileen Remold-O'Donnell,Denisa D. Wagner,Denisa D. Wagner +10 more
TL;DR: Neutrophil elastase deficiency had no significant effect on thrombosis in the inferior vena cava stenosis model and is not required for mouse neutrophil NET production in vitro with non‐infectious stimuli.
Journal ArticleDOI
Peptidylarginine deiminase 4 promotes age-related organ fibrosis
Kimberly Martinod,Kimberly Martinod,Thilo Witsch,Thilo Witsch,Luise Erpenbeck,Luise Erpenbeck,Alexander Savchenko,Alexander Savchenko,Hideki Hayashi,Hideki Hayashi,Deya Cherpokova,Deya Cherpokova,Maureen Gallant,Maximilian Mauler,Stephen M. Cifuni,Denisa D. Wagner,Denisa D. Wagner +16 more
TL;DR: It is concluded that PAD4 regulates age-related organ fibrosis and dysfunction and proposes a role for NETs in cardiac fibrosis, and DNase 1 was given to assess the effects of extracellular chromatin.
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Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation
Maximilian Mauler,Nadine Herr,Claudia Schoenichen,Thilo Witsch,Timoteo Marchini,Carmen Härdtner,Christoph Koentges,Korbinian Kienle,Korbinian Kienle,Véronique Ollivier,Véronique Ollivier,Maximilian Schell,Ludwig Dorner,Christopher Wippel,Daniela Stallmann,Claus Normann,Claus Normann,Heiko Bugger,Paul Walther,Dennis Wolf,Dennis Wolf,Ingo Ahrens,Tim Lämmermann,Benoît Ho-Tin-Noé,Benoît Ho-Tin-Noé,Klaus Ley,Christoph Bode,Ingo Hilgendorf,Daniel Duerschmied +28 more
TL;DR: Serotonin is identified as a potent therapeutic target in neutrophil-dependent thromboinflammation during myocardial reperfusion injury and patients with depression using serotonin reuptake inhibition are presented with suppressed levels of CD11b surface expression on neutrophils and lower myeloperoxidase levels in blood.
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Dual-contrast molecular imaging allows noninvasive characterization of myocardial ischemia/reperfusion injury after coronary vessel occlusion in mice by magnetic resonance imaging.
Dominik von Elverfeldt,Alexander Maier,Daniel Duerschmied,Moritz Braig,Thilo Witsch,Xiaowei Wang,Maximilian Mauler,Irene Neudorfer,Marius Menza,Marco Idzko,Andreas Zirlik,Timo Heidt,Peter Bronsert,Christoph Bode,Karlheinz Peter,Constantin von zur Mühlen +15 more
TL;DR: In this article, a dual-noninvasive imaging approach using molecular magnetic resonance imaging in an in vivo mouse model of myocardial ischemia and reperfusion was developed.
Journal ArticleDOI
Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.
Thilo Witsch,Pawel Turowski,Elpidoforos Sakkas,Elpidoforos Sakkas,Gero Niess,Gero Niess,Simone Becker,Simone Becker,Susanne Herold,Konstantin Mayer,István Vadász,Jesse D. Roberts,Werner Seeger,Werner Seeger,Rory E. Morty,Rory E. Morty +15 more
TL;DR: Roles for lysyl hydroxylases in normal lung development, as well as in perturbed late lung development associated with BPD are pointed to.