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Christoph Koentges
Researcher at University of Freiburg
Publications - 17
Citations - 593
Christoph Koentges is an academic researcher from University of Freiburg. The author has contributed to research in topics: Heart failure & Mitochondrion. The author has an hindex of 9, co-authored 15 publications receiving 438 citations. Previous affiliations of Christoph Koentges include University Medical Center Freiburg.
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Journal ArticleDOI
SIRT3 deficiency impairs mitochondrial and contractile function in the heart
Christoph Koentges,Katharina Pfeil,Tilman Schnick,Sebastian Wiese,Rabea Dahlbock,Maria C. Cimolai,Maximilian Meyer-Steenbuck,Katarina Cenkerova,Michael M. Hoffmann,Carsten Jaeger,Katja E. Odening,Bernd Kammerer,Lutz Hein,Christoph Bode,Heiko Bugger +14 more
TL;DR: SIRT3−/− mice developed progressive age-related deterioration of cardiac function, as evidenced by a decrease in ejection fraction and an increase in enddiastolic volume at 24 but not 8 weeks of age using echocardiography.
Journal Article
Abstract 14989: SIRT3 Deficiency Impairs Mitochondrial and Contractile Function in the Heart
Christoph Koentges,Katharina Pfeil,Tilman Schnick,Katarina Cenkerova,Carsten Jaeger,Bernd Kammerer,Lutz Hein,Christoph Bode,Heiko Bugger +8 more
TL;DR: Lack of SIRT3 impairs mitochondrial and contractile function in the heart, likely due to increased acetylation of various energy metabolic proteins and subsequent myocardial energy depletion.
Journal ArticleDOI
Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation
Maximilian Mauler,Nadine Herr,Claudia Schoenichen,Thilo Witsch,Timoteo Marchini,Carmen Härdtner,Christoph Koentges,Korbinian Kienle,Korbinian Kienle,Véronique Ollivier,Véronique Ollivier,Maximilian Schell,Ludwig Dorner,Christopher Wippel,Daniela Stallmann,Claus Normann,Claus Normann,Heiko Bugger,Paul Walther,Dennis Wolf,Dennis Wolf,Ingo Ahrens,Tim Lämmermann,Benoît Ho-Tin-Noé,Benoît Ho-Tin-Noé,Klaus Ley,Christoph Bode,Ingo Hilgendorf,Daniel Duerschmied +28 more
TL;DR: Serotonin is identified as a potent therapeutic target in neutrophil-dependent thromboinflammation during myocardial reperfusion injury and patients with depression using serotonin reuptake inhibition are presented with suppressed levels of CD11b surface expression on neutrophils and lower myeloperoxidase levels in blood.
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SIRT3 in Cardiac Physiology and Disease
TL;DR: The proposal that activation of SIRT3 may represent a promising therapeutic strategy to improve mitochondrial derangements in various cardiac pathologies is proposed.
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Growth‐inhibitory and chemosensitizing effects of the glutathione‐S‐transferase‐π‐activated nitric oxide donor PABA/NO in malignant gliomas
Evangelos Kogias,Nadja Osterberg,Brunhilde Baumer,Nikolaos Psarras,Christoph Koentges,Anna Papazoglou,Joseph E. Saavedra,Larry K. Keefer,Astrid Weyerbrock +8 more
TL;DR: PABA/NO has potent antiproliferative effects, sensitizes U87 glioma cells to TMZ in vitro and shows some in vivo efficacy, and further studies are still required to consolidate the role of NO donor therapy in gliomas treatment.