Thomas Brunner

TL;DR: Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage.

TL;DR: This work shows that the Fas/CD95 receptor, which can transduce a potent apoptotic signal when ligated, is rapidly expressed following activation of T-cell hybridomas, as is its functional, membrane-bound ligand8.

TL;DR: Calpain-mediated Atg5 cleavage provokes apoptotic cell death, therefore, represents a molecular link between autophagy and apoptosis — a finding with potential importance for clinical anticancer therapies.

TL;DR: It is reported that activation of the two transcription factors NF-kappa B and AP-1 is crucially involved in FasL expression induced by etoposid, teniposide, and UV irradiation and contributes to stress-induced apoptosis via the expression of FasL.

TL;DR: It is reported that, in the presence of IL-4, mast and basophilic cell lines can provide the cell contact signals that are required for IgE synthesis, suggesting that mast cells and Basophils may play a key role in allergy not only by producing inflammatory mediators, but also by directly regulating IgE production independently of T cells.