T
Thomas Comptdaer
Researcher at university of lille
Publications - 13
Citations - 259
Thomas Comptdaer is an academic researcher from university of lille. The author has contributed to research in topics: LRRK2 & Medicine. The author has an hindex of 6, co-authored 10 publications receiving 162 citations. Previous affiliations of Thomas Comptdaer include Lille University of Science and Technology & French Institute of Health and Medical Research.
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Journal ArticleDOI
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
Jesús Madero-Pérez,Elena Fdez,Belén Fernández,Antonio Ordóñez,Marian Blanca Ramírez,Patricia Gómez-Suaga,Dieter Waschbüsch,Evy Lobbestael,Veerle Baekelandt,Angus C. Nairn,Javier Ruiz-Martínez,Ana Aiastui,Adolfo López de Munain,Pawel Lis,Thomas Comptdaer,Jean-Marc Taymans,Marie-Christine Chartier-Harlin,A Beilina,Adriano Gonnelli,Mark R. Cookson,Elisa Greggio,Sabine Hilfiker +21 more
TL;DR: It is shown that pathogenic LRRK2 causes deficits in centrosomal positioning with effects on neurite outgrowth, cell polarization and directed migration, and which can be detected in peripheral cells derived from L RRK2-PD patients as compared to healthy controls, andWhich are reversed upon LRRk2 kinase inhibition.
Journal ArticleDOI
Transcriptomic signatures of brain regional vulnerability to Parkinson's disease.
Arlin Keo,Arlin Keo,Ahmed Mahfouz,Ahmed Mahfouz,Angela Ingrassia,Jean Pascal Meneboo,Céline Villenet,Eugénie Mutez,Eugénie Mutez,Thomas Comptdaer,Boudewijn P. F. Lelieveldt,Boudewijn P. F. Lelieveldt,Martin Figeac,Marie-Christine Chartier-Harlin,Wilma D.J. van de Berg,Jacobus J. van Hilten,Marcel J. T. Reinders,Marcel J. T. Reinders +17 more
TL;DR: Transcriptomic signatures across brain regions involved in Braak Lewy body stages in non-neurological adults from the Allen Human Brain Atlas are identified and genes and modules involved in the selective regional vulnerability and the progression of Parkinson’s disease are identified.
Journal ArticleDOI
Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease.
Eugénie Mutez,Aurore Nkiliza,Karim Belarbi,Amélie de Broucker,Christel Vanbesien-Mailliot,Séverine Bleuse,A. Duflot,Thomas Comptdaer,Pierre Semaille,Renaud Blervaque,David Hot,Frédéric Leprêtre,Martin Figeac,Alain Destée,Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin +15 more
TL;DR: Analysis of PBMC data and other publicly available transcriptome datasets showed that deregulation of the immune system, endocytosis and eukaryotic initiation factor 2 (EIF2) signaling are the main features of transcriptome profiles in PD.
Journal ArticleDOI
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
Belén Fernández,Antonio Ordóñez,Elena Fdez,Eugénie Mutez,Eugénie Mutez,Thomas Comptdaer,Thomas Comptdaer,Coline Leghay,Coline Leghay,Alexandre Kreisler,Alexandre Kreisler,Clémence Simonin,Clémence Simonin,Laurine Vandewynckel,Luc Defebvre,Alain Destée,Alain Destée,Séverine Bleuse,Jean-Marc Taymans,Jean-Marc Taymans,Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Sabine Hilfiker,Sabine Hilfiker +23 more
TL;DR: It is suggested that LCLs may be a valuable resource for LRRK2 research, and that determination of centrosomal cohesion deficits may assist in the stratification of a subset of sporadic PD patients.
Journal ArticleDOI
Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice
Elodie Cuvelier,Mathieu Méquinion,Coline Leghay,William Sibran,Alicia Stievenard,Alessia Sarchione,Marie Amandine Bonte,Christel Vanbesien-Mailliot,Odile Viltart,Kevin Saitoski,Emilie Caron,Alexandra Labarthe,Thomas Comptdaer,Pierre Semaille,Hélène Carrié,Eugénie Mutez,Bernard Gressier,Alain Destée,Marie-Christine Chartier-Harlin,Karim Belarbi +19 more
TL;DR: Results suggest that metabolic alterations are an important phenotype of alpha-synuclein overexpression in mice and that impaired STAT3 activation and mTORC2 levels in the hypothalamus may underlie the disruption of feeding regulation and energy metabolism in Thy1-aSYN mice.