Andrea S. Pollard

TL;DR: It is shown that incubation temperature influences motility and limb bone growth in West African Dwarf crocodiles, producing altered limb proportions which may, influence post-hatching performance and provide new insights into how environmental factors can be integrated to influence cellular activity in growing bones and ultimately gross limb morphology, to generate phenotypic variation during prenatal development.

TL;DR: This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development.

TL;DR: The results implicate GPC6 as a novel determinant of BMD, and also identify abnormal skeletal phenotypes in knockout mice associated with a further 100 prioritized genes.

TL;DR: In vivo evidence is provided that noncanonical TR signaling exerts physiologically important cardiometabolic effects that are distinct from canonical actions, challenging the current paradigm that in vivo physiological TH action is mediated exclusively via regulation of gene transcription at the nuclear level.

TL;DR: Specific scenarios in which the redeployment of these embryonic processes may contribute to disease development are highlighted, with the foresight that deciphering those mechanisms regulating pathological changes and loss of cartilage stability will aid future research into effective disease-modifying therapies.