T
Thomas P. Wyche
Researcher at Merck & Co.
Publications - 37
Citations - 1287
Thomas P. Wyche is an academic researcher from Merck & Co.. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 34 publications receiving 1042 citations. Previous affiliations of Thomas P. Wyche include Harvard University & University of Wisconsin-Madison.
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Journal ArticleDOI
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.
Chun-Jun Guo,Fang-Yuan Chang,Thomas P. Wyche,Keriann M. Backus,Timothy M. Acker,Funabashi Masanori,Mao Taketani,Mohamed S. Donia,Stephen Nayfach,Katherine S. Pollard,Charles S. Craik,Benjamin F. Cravatt,Jon Clardy,Christopher A. Voigt,Michael A. Fischbach +14 more
TL;DR: The findings show that an approach combining bioinformatics, synthetic biology, and heterologous gene cluster expression can rapidly expand the knowledge of the metabolic potential of the microbiota while avoiding the challenges of cultivating fastidious commensals.
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Microbial Strain Prioritization Using Metabolomics Tools for the Discovery of Natural Products
Yanpeng Hou,Doug R. Braun,Cole R. Michel,Jonathan L. Klassen,Navid Adnani,Thomas P. Wyche,Tim S. Bugni +6 more
TL;DR: This work evaluated LC/MS-PCA for strain selection to support drug discovery, for the discovery of unique natural products, and for rapid assessment of regulation of natural product production.
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Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin
Gavin Carr,Michael Poulsen,Jonathan L. Klassen,Yanpeng Hou,Thomas P. Wyche,Tim S. Bugni,Cameron R. Currie,Jon Clardy +7 more
TL;DR: It is proposed that vinylamycin’s structure be revised from 3 to 4, based on a comparison of predicted and experimental 1H and 13C NMR chemical shifts.
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Forazoline A: Marine‐Derived Polyketide with Antifungal In Vivo Efficacy
Thomas P. Wyche,Jeff S. Piotrowski,Yanpeng Hou,Doug R. Braun,Raamesh Deshpande,Sean J. McIlwain,Irene M. Ong,Chad L. Myers,Ilia A. Guzei,William M. Westler,David R. Andes,Tim S. Bugni +11 more
TL;DR: This approach represents the first example of determining direct (13)C-(15)N connectivity for a natural product, and proposes that forazoline A operated through a new mechanism of action with a phenotypic outcome of disrupting membrane integrity.
Journal ArticleDOI
Structure and biosynthesis of the antibiotic bottromycin D.
Yanpeng Hou,Ma. Diarey B. Tianero,Jason C. Kwan,Thomas P. Wyche,Cole R. Michel,Gregory A. Ellis,E Vazquez-Rivera,Doug R. Braun,Warren E. Rose,Eric W. Schmidt,Tim S. Bugni +10 more
TL;DR: LCMS-based metabolomics was applied to analyze extracts of 50 Streptomyes spp.