T
Thomas Vierbuchen
Researcher at Stanford University
Publications - 16
Citations - 6104
Thomas Vierbuchen is an academic researcher from Stanford University. The author has contributed to research in topics: Cellular differentiation & Transcription factor. The author has an hindex of 12, co-authored 14 publications receiving 5479 citations. Previous affiliations of Thomas Vierbuchen include Kettering University & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Direct conversion of fibroblasts to functional neurons by defined factors
Thomas Vierbuchen,Austin Ostermeier,Zhiping P. Pang,Yuko Kokubu,Thomas C. Südhof,Marius Wernig +5 more
TL;DR: In this paper, a combination of three transcription factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, was used to convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro.
Journal ArticleDOI
Induction of human neuronal cells by defined transcription factors
Zhiping P. Pang,Nan Yang,Thomas Vierbuchen,Austin Ostermeier,Daniel R. Fuentes,Troy Q. Yang,Ami Citri,Vittorio Sebastiano,Samuele Marro,Thomas C. Südhof,Marius Wernig +10 more
TL;DR: The data demonstrate that non-neural human somatic cells, as well as pluripotent stem cells, can be converted directly into neurons by lineage-determining transcription factors.
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Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.
Orly L. Wapinski,Thomas Vierbuchen,Kun Qu,Qian Yi Lee,Soham Chanda,Daniel R. Fuentes,Paul G. Giresi,Yi Han Ng,Samuele Marro,Norma F. Neff,Daniela Drechsel,Ben Martynoga,Diogo S. Castro,Ashley E. Webb,Thomas C. Südhof,Anne Brunet,François Guillemot,Howard Y. Chang,Howard Y. Chang,Marius Wernig +19 more
TL;DR: A precise match between pioneer factors and the chromatin context at key target genes is determinative for transdifferentiation to neurons and likely other cell types.
Journal ArticleDOI
AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection
Thomas Vierbuchen,Emi Ling,Christopher J. Cowley,Cameron H. Couch,Xiaofeng Wang,David A. Harmin,Charles W. M. Roberts,Michael E. Greenberg +7 more
TL;DR: It is demonstrated how environmental signals acting via FOS/JUN and BAF coordinate with cell-type-specific TFs to select enhancer repertoires that enable differentiation during development.
Journal ArticleDOI
Generation of oligodendroglial cells by direct lineage conversion
Nan Yang,J. Bradley Zuchero,Henrik Ahlenius,Samuele Marro,Yi Han Ng,Thomas Vierbuchen,John S. Hawkins,Richard Geissler,Ben A. Barres,Marius Wernig +9 more
TL;DR: The generation of induced OPCs (iOPCs) by direct lineage conversion was reported, which gave rise to mature oligodendrocytes that could ensheath multiple host axons when co-cultured with primary dorsal root ganglion cells and formed myelin after transplantation into shiverer mice.