Y
Yi Han Ng
Researcher at Stanford University
Publications - 18
Citations - 1993
Yi Han Ng is an academic researcher from Stanford University. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 12, co-authored 16 publications receiving 1593 citations. Previous affiliations of Yi Han Ng include University of Wisconsin-Madison & Agency for Science, Technology and Research.
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Journal ArticleDOI
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.
Orly L. Wapinski,Thomas Vierbuchen,Kun Qu,Qian Yi Lee,Soham Chanda,Daniel R. Fuentes,Paul G. Giresi,Yi Han Ng,Samuele Marro,Norma F. Neff,Daniela Drechsel,Ben Martynoga,Diogo S. Castro,Ashley E. Webb,Thomas C. Südhof,Anne Brunet,François Guillemot,Howard Y. Chang,Howard Y. Chang,Marius Wernig +19 more
TL;DR: A precise match between pioneer factors and the chromatin context at key target genes is determinative for transdifferentiation to neurons and likely other cell types.
Journal ArticleDOI
Generation of oligodendroglial cells by direct lineage conversion
Nan Yang,J. Bradley Zuchero,Henrik Ahlenius,Samuele Marro,Yi Han Ng,Thomas Vierbuchen,John S. Hawkins,Richard Geissler,Ben A. Barres,Marius Wernig +9 more
TL;DR: The generation of induced OPCs (iOPCs) by direct lineage conversion was reported, which gave rise to mature oligodendrocytes that could ensheath multiple host axons when co-cultured with primary dorsal root ganglion cells and formed myelin after transplantation into shiverer mice.
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Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model
Pia Rivetti di Val Cervo,Roman A. Romanov,Roman A. Romanov,Giada Spigolon,Débora Masini,Elisa Martín-Montañez,Enrique M. Toledo,Gioele La Manno,Michael Feyder,Christian Pifl,Yi Han Ng,Sara Padrell Sánchez,Sten Linnarsson,Marius Wernig,Tibor Harkany,Tibor Harkany,Gilberto Fisone,Ernest Arenas +17 more
TL;DR: This work uses three transcription factors, NEUROD1, ASCL1 and LMX1A, and the microRNA miR218 to reprogram human and mouse astrocytes in vitro and in vivo into induced dopamine neurons (iDANs), which may enable clinical therapies for Parkinson's disease by delivery of genes rather than cells.
Journal ArticleDOI
Generation of pure GABAergic neurons by transcription factor programming
Nan Yang,Soham Chanda,Samuele Marro,Yi Han Ng,Justyna A. Janas,Daniel Haag,Cheen Euong Ang,Yunshuo Tang,Quetzal Flores,Moritz Mall,Orly L. Wapinski,Mavis Li,Henrik Ahlenius,John L.R. Rubenstein,Howard Y. Chang,Arturo Alvarez Buylla,Thomas C. Südhof,Marius Wernig +17 more
TL;DR: It is shown that transient expression of the transcription factors Ascl1 and Dlx2 (AD) induces the generation of exclusively GABAergic neurons from human PSCs with a high degree of synaptic maturation, establishing that human collybistin, the loss of gene function of which causes severe encephalopathy, is required for inhibitory synaptic function.
Journal ArticleDOI
Induced Neuronal Cells: How to Make and Define a Neuron
TL;DR: The most recent developments in induced neuronal (iN) cells are summarized and criteria to help define and categorize iN cells that take into account the complexity of neuronal identity are suggested.