Orly L. Wapinski

TL;DR: The evidence linking lncRNAs to diverse human diseases is reviewed and fundamental concepts in lncRNA biology that still need to be clarified are highlighted to provide a robust framework for lnc RNA genetics.

TL;DR: An enhancer-like lncRNA termed NeST is shown to be causal for all phenotypes conferred by murine viral susceptibility locus Tmevp3, and regulates epigenetic marking of IFN-γ-encoding chromatin, expression of IFn-γ, and susceptibility to a viral and a bacterial pathogen.

TL;DR: A precise match between pioneer factors and the chromatin context at key target genes is determinative for transdifferentiation to neurons and likely other cell types.

TL;DR: It is shown that targeted deletion of mouse Hotair lncRNA leads to derepression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones.

TL;DR: It is shown that transient expression of the transcription factors Ascl1 and Dlx2 (AD) induces the generation of exclusively GABAergic neurons from human PSCs with a high degree of synaptic maturation, establishing that human collybistin, the loss of gene function of which causes severe encephalopathy, is required for inhibitory synaptic function.