Thomas W. Abrams

TL;DR: This article provides a modern summary of the characteristics defining habituation, and can serve as a convenient primer for those whose research involves stimulus repetition.

TL;DR: It appears that several transmitters can converge to produce presynaptic facilitation in the sensory neurons of the defensive withdrawal reflex, and all of the transmitters studied here, the SCPs and serotonin, act via an identical molecular cascade.

TL;DR: The dependence of cyclase activation on the temporal pattern of Ca2+ and transmitter addition is explored and it is suggested that the dually regulated adenylate cyclase might underlie the temporal requirements for effective classical conditioning in this system.

TL;DR: It is found that the mechanism postulated by Hebb is neither necessary nor sufficient to produce the associative change in synaptic strength that underlies conditioning in Aplysia, and impulse activity in the presynaptic cell must be paired with facilitatory input, supporting the hypothesis that the temporal specificity of classical conditioning in

TL;DR: It is found that cAMP plays a major role in the spike-broadening effects of facilitatory transmitter; however, broadening requires higher levels of activation of the cAMP-dependent kinase than does increasing excitability.