T
Thomas Yeoh
Researcher at Victor Chang Cardiac Research Institute
Publications - 10
Citations - 1034
Thomas Yeoh is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: Cardiomyopathy & Dilated cardiomyopathy. The author has an hindex of 10, co-authored 10 publications receiving 979 citations. Previous affiliations of Thomas Yeoh include University of Sydney.
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Journal ArticleDOI
Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway.
Christopher Semsarian,Ming-Jie Wu,Yue-Kun Ju,Tadeusz Marciniec,Thomas Yeoh,David G. Allen,Richard P. Harvey,Richard P. Harvey,Robert M. Graham,Robert M. Graham +9 more
TL;DR: It is proposed that growth-factor-induced skeletal-muscle hypertrophy and changes in myofibre phenotype are mediated by calcium mobilization and are critically regulated by the calcineurin/NF-ATc1 signalling pathway.
Journal ArticleDOI
Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: Associations with atrial septal defect and hypoplastic left heart syndrome
David A. Elliott,Edwin P. Kirk,Edwin P. Kirk,Edwin P. Kirk,Thomas Yeoh,Suchitra Chandar,Fiona Haslam McKenzie,Peter J. Taylor,Paul Grossfeld,Diane Fatkin,Owen Jones,Peter Hayes,Michael P. Feneley,Richard P. Harvey,Richard P. Harvey +14 more
TL;DR: Screening for NKX2-5 mutations may be warranted in individuals with ASD and a positive family history, irrespective of the presence or absence of AV conduction block, according to the findings.
Journal ArticleDOI
The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner
Steve Palmer,Nicola Groves,Aaron Schindeler,Thomas Yeoh,Christine Biben,Cheng Chun Wang,Duncan B. Sparrow,Louise Barnett,Nancy A. Jenkins,Neal G. Copeland,Frank Koentgen,Tim Mohun,Richard P. Harvey,Richard P. Harvey +13 more
TL;DR: The dynamic cytoskeletal localization of Csl and its dominant effects on cell shape and behavior and transcription factor activity suggest that Csl plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.
Journal ArticleDOI
Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy.
Mauro W. Costa,Guanglan Guo,Orit Wolstein,Molly Vale,Maria Leticia Castro,Libin Wang,Robyn Otway,Peter Riek,Natalie Cochrane,Milena B. Furtado,Christopher Semsarian,Robert G. Weintraub,Thomas Yeoh,Christopher S. Hayward,Anne Keogh,Peter S. Macdonald,Michael P. Feneley,Robert M. Graham,Jonathan G. Seidman,Christine E. Seidman,Nadia Rosenthal,Diane Fatkin,Richard P. Harvey +22 more
TL;DR: Certain NKX2-5 homeodomain mutations show abnormal protein degradation via the Ubiquitin-proteasome system and partially impaired transcriptional activity, which can impair heart development and mature heart function and contribute to NKX 2-5–related cardiomyopathies with graded severity.
Journal ArticleDOI
Myosin light chain gene expression associated with disease states of the human heart.
Toby Trahair,Thomas Yeoh,T. Cartmill,Anne Keogh,Phillip Spratt,V. Chang,C.G. dos Remedios,Peter W. Gunning +7 more
TL;DR: It is found that the level of MLC2V mRNA per microgram total ventricular RNA is very similar in CM, CCD and normal human samples, while MLC1V mRNA levels tend to be reduced in both CM and CCD samples, and in CM patients in end-stage failure, expression of M LC1A is barely detectable.