T
Tijana Perovic
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 4
Citations - 145
Tijana Perovic is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Endothelial stem cell & Sprouting angiogenesis. The author has an hindex of 3, co-authored 4 publications receiving 68 citations.
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Journal ArticleDOI
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression
Anne-Clémence Vion,Anne-Clémence Vion,Silvanus Alt,Alexandra Klaus-Bergmann,Anna Szymborska,Tuyu Zheng,Tijana Perovic,Adel Hammoutene,Adel Hammoutene,Marta Bastos Oliveira,Eireen Bartels-Klein,Irene Hollfinger,Pierre-Emmanuel Rautou,Pierre-Emmanuel Rautou,Miguel O. Bernabeu,Miguel O. Bernabeu,Holger Gerhardt +16 more
TL;DR: In this article, the authors show that endothelial cells in the developing mouse retina form and use luminal primary cilia to stabilize vessel connections selectively in parts of the remodeling vascular plexus experiencing low and intermediate shear stress.
Journal ArticleDOI
Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways.
Anne-Clémence Vion,Tijana Perovic,Charlie Petit,Irene Hollfinger,Eireen Bartels-Klein,Emmanuelle Frampton,Emma Gordon,Emma Gordon,Lena Claesson-Welsh,Holger Gerhardt +9 more
TL;DR: In this article, the authors used flow-induced shear stress and VEGF-A treatment on endothelial cells in vitro, showing that the response to the magnitude of a mechanical stimulus is influenced by the concentration of a chemical stimulus, and vice versa.
Posted ContentDOI
Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks
Qi Zhou,Tijana Perovic,Ines Fechner,Lowell T. Edgar,Peter R. Hoskins,Holger Gerhardt,Timm Krüger,Miguel O. Bernabeu +7 more
TL;DR: RBC dynamics are fundamental for establishing the regional WSS differences driving vascular remodelling via their ability to modulate effective viscosity, and are reported to report a strong association between vessel regression and RBC depletion.
Journal ArticleDOI
Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks.
Qi Zhou,Tijana Perovic,Ines Fechner,Lowell T. Edgar,Peter R. Hoskins,Peter R. Hoskins,Holger Gerhardt,Timm Krüger,Miguel O. Bernabeu +8 more
TL;DR: In this article, the presence of erythrocytes (widely known as red blood cells (RBCs)) and their impact on haemodynamics affect vascular remodelling is investigated.