T
Tim Magnus
Researcher at University of Hamburg
Publications - 154
Citations - 7001
Tim Magnus is an academic researcher from University of Hamburg. The author has contributed to research in topics: Microglia & Inflammation. The author has an hindex of 38, co-authored 133 publications receiving 5338 citations. Previous affiliations of Tim Magnus include Hamburg University of Technology & Eppendorf (Germany).
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Journal ArticleDOI
Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo
Mélanie Demeules,Allan Scarpitta,Romain Hardet,Henri Gondé,Catalina Abad,Marine Blandin,Stephan Menzel,Yinghui Duan,Björn Rissiek,Tim Magnus,Anna Marei Mann,Friedrich Koch-Nolte,Sahil Adriouch +12 more
TL;DR: P2X7-potentiation by a nanobody-based biologic was not effective alone to control tumor growth but enhanced tumor control and immune responses when used in combination with oxaliplatin chemotherapy.
Journal ArticleDOI
Recurrent amnesia caused by early seizures after hippocampal infarction: a case report
Eckhard Schlemm,Tim Magnus,Leander Rimmele,Justine Münsterberg,Maxim Bester,Simon S Kessner,Mathias Gelderblom,Christian Gerloff +7 more
TL;DR: In this paper , the authors report the case of a patient with recurrent episodes of disturbed memory suggestive of transient epileptic amnesia, and a focal hippocampal lesion typically associated with transient global amnesia.
Journal Article
Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke
Luting Poh,Sung-Wook Kang,Sang-Ha Baik,Gavin Yong Quan Ng,David T. She,Priyanka Balaganapathy,S. Thameem Dheen,Tim Magnus,Mathias Gelderblom,Christopher G. Sobey,Edward H. Koo,David Y. Fann,Thiruma V. Arumugam +12 more
TL;DR: Evidence is provided that the NLRC4 inflammasome complex mediates the inflammatory response, as well as apoptotic and pyroptotic cell death in microglial cells under in vitro and in vivo ischemic conditions.
Journal ArticleDOI
A preclinical randomized controlled multi-centre trial of anti-interleukin-17A treatment for acute ischaemic stroke
Mathias Gelderblom,S. Koch,Jan K. Strecker,Carina Jørgensen,Lidia Garcia-Bonilla,Peter Ludewig,I. S. Schädlich,Marius Piepke,Karoline Degenhardt,Christian Bernreuther,Hans O. Pinnschmidt,Thiruma V. Arumugam,Götz Thomalla,Cornelius Faber,Jan Sedlacik,Christian Gerloff,Jens Minnerup,Bettina Hjelm Clausen,Josef Anrather,Tim Magnus +19 more
TL;DR: In this article , the authors investigated the efficacy of an interleukin-17A neutralizing antibody in a multi-centre preclinical randomized controlled trial using a murine ischaemia reperfusion stroke model.
Posted ContentDOI
Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo
Yuqi Gui,Yohan Kim,Santra Brenna,Maximilian Wilmes,Hannah Voß,Hartmut Schlüter,Michaela Schweizer,Hermann C. Altmeppen,Tim Magnus,Efrat Levy,Berta Puig +10 more
TL;DR: In this paper , the authors performed liquid chromatography coupled to mass spectrometry (LC-MS)-based proteomics of synaptosomes isolated from the ipsilateral hemispheres of mice subjected to experimental stroke at different time points (24 h, 4 and 7 days) and compared them to sham-operated mice.