T
Tim Magnus
Researcher at University of Hamburg
Publications - 154
Citations - 7001
Tim Magnus is an academic researcher from University of Hamburg. The author has contributed to research in topics: Microglia & Inflammation. The author has an hindex of 38, co-authored 133 publications receiving 5338 citations. Previous affiliations of Tim Magnus include Hamburg University of Technology & Eppendorf (Germany).
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Journal ArticleDOI
AST-120 Reduces Neuroinflammation Induced by Indoxyl Sulfate in Glial Cells.
Simona Adesso,Irene Paterniti,Salvatore Cuzzocrea,Masaki Fujioka,Giuseppina Autore,Tim Magnus,Aldo Pinto,Stefania Marzocco +7 more
TL;DR: It is demonstrated that sera of CKD patients induced a significant inflammation in astrocyte cells which was proportional to IS sera concentrations, and that the IS adsorbent, AST-120, reduced this inflammatory response.
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Different Roles of Mitochondria in Cell Death and Inflammation: Focusing on Mitochondrial Quality Control in Ischemic Stroke and Reperfusion.
Marianna Carinci,Bianca Vezzani,Simone Patergnani,Peter Ludewig,Katrin Lessmann,Tim Magnus,Ilaria Casetta,Maura Pugliatti,Paolo Pinton,Carlotta Giorgi +9 more
TL;DR: In this article, the principal mitochondrial molecular mechanisms compromised during ischemic and reperfusion injury were explored, and potential neuroprotective strategies targeting mitochondrial dysfunction and mitochondrial homeostasis were delineated.
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In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells.
Björn Rissiek,Marco Lukowiak,Friederike Raczkowski,Tim Magnus,Hans-Willi Mittrücker,Friedrich Koch-Nolte +5 more
TL;DR: It is concluded that in vivo blockade of ARTC2.2 during cell preparation by nanobody s+16a injection represents a valuable strategy to study the role and function of liver Trm in mice.
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Deficiency in serine protease inhibitor neuroserpin exacerbates ischemic brain injury by increased postischemic inflammation.
Mathias Gelderblom,Melanie Neumann,Peter Ludewig,Christian Bernreuther,Susanne Krasemann,Priyadharshini Arunachalam,Christian Gerloff,Markus Glatzel,Tim Magnus +8 more
TL;DR: Excessive microglial activation in Ns−/− mice mediated by an increased activity of tPA results in a worse outcome further underscoring the potential detrimental proinflammatory effects of t PA.
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GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice
Berta Puig,Hermann C. Altmeppen,Luise Linsenmeier,Karima Chakroun,Florian Wegwitz,Ulrike K. Piontek,Jörg Tatzelt,Jörg Tatzelt,Clive Bate,Tim Magnus,Markus Glatzel +10 more
TL;DR: The results are the first to demonstrate in vivo, that the G PI-anchor signal sequence plays a fundamental role in the GPI-anchors composition, dictating the subcellular localization of a given protein and, in the case of PrPC, influencing the development of prion disease.