T
Tim Magnus
Researcher at University of Hamburg
Publications - 154
Citations - 7001
Tim Magnus is an academic researcher from University of Hamburg. The author has contributed to research in topics: Microglia & Inflammation. The author has an hindex of 38, co-authored 133 publications receiving 5338 citations. Previous affiliations of Tim Magnus include Hamburg University of Technology & Eppendorf (Germany).
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Journal ArticleDOI
Toll-Like Receptor 3 Is a Negative Regulator of Embryonic Neural Progenitor Cell Proliferation
Justin D. Lathia,Eitan Okun,Sung-Chun Tang,Kathleen J. Griffioen,Aiwu Cheng,Mohamed R. Mughal,Gloria Laryea,Pradeep K. Selvaraj,Charles ffrench-Constant,Tim Magnus,Thiruma V. Arumugam,Mark P. Mattson +11 more
TL;DR: A novel role for TLR3 is revealed in the negative regulation of NPC proliferation in the developing brain in wild type but notTLR3−/−-derived NPCs.
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Herpes simplex virus–1 encephalitis can trigger anti-NMDA receptor encephalitis: Case report
Frank Leypoldt,Maarten J. Titulaer,Esther Aguilar,Janine Walther,Marlene Bönstrup,Stefanie Havemeister,Bianca Teegen,Marc Lütgehetmann,Michael Rosenkranz,Tim Magnus,Josep Dalmau +10 more
TL;DR: An adult with this disorder is reported, it is demonstrated that synthesis of NMDAR antibodies began after HSVE, and relapsing symptoms were due to steroid-responsive anti-NMDAR encephalitis.
Journal ArticleDOI
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: Implications for immune responses and autoimmunity in the CNS
Tim Magnus,Bettina Schreiner,Thomas Korn,Carolyn Jack,Hong Guo,Jack P. Antel,Igal Ifergan,Lieping Chen,Felix Bischof,Amit Bar-Or,Heinz Wiendl +10 more
TL;DR: The data propose microglial B7-H1 as an important immune inhibitory molecule capable of downregulating T-cell activation in the CNS and thus confining immunopathological damage.
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Danger signals in stroke and their role on microglia activation after ischemia
TL;DR: The role of the most important DAMPs, high mobility group box 1, heat and cold shock proteins, purines, and peroxiredoxins, are addressed and intracellular pathways activated by DAMPs in microglia are illuminated.
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Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease
Frank Leypoldt,Ralph Buchert,Ingo Kleiter,Jörg Marienhagen,Mathias Gelderblom,Tim Magnus,Josep Dalmau,Christian Gerloff,Jan Lewerenz +8 more
TL;DR: A characteristic change in cerebral glucose metabolism during NMDAR-ab encephalitis is an increased frontotemporal-to-occipital gradient that correlates with disease severity, which might be a consequence of impaired N MDAR function.