T
Tim Magnus
Researcher at University of Hamburg
Publications - 154
Citations - 7001
Tim Magnus is an academic researcher from University of Hamburg. The author has contributed to research in topics: Microglia & Inflammation. The author has an hindex of 38, co-authored 133 publications receiving 5338 citations. Previous affiliations of Tim Magnus include Hamburg University of Technology & Eppendorf (Germany).
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Journal ArticleDOI
Magnetic Particle Imaging for Real-Time Perfusion Imaging in Acute Stroke
Peter Ludewig,Nadine Gdaniec,Jan Sedlacik,Nils D. Forkert,Patryk Szwargulski,Matthias Graeser,Gerhard Adam,Michael G. Kaul,Kannan M. Krishnan,R. Matthew Ferguson,Amit P. Khandhar,Piotr Walczak,Piotr Walczak,Jens Fiehler,Götz Thomalla,Christian Gerloff,Tobias Knopp,Tim Magnus,Tim Magnus +18 more
TL;DR: For the first time, it is shown that MPI could be used as a diagnostic tool for relevant diseases in vivo, such as an ischemic stroke, due to its shorter image acquisition times and increased temporal resolution compared to that of MRI or CT.
Journal ArticleDOI
Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination.
Dietrich Mack,Joachim Riedewald,Holger Rohde,Tim Magnus,Hubert Feucht,Holger A. Elsner,Rainer Laufs,Mark E. Rupp +7 more
TL;DR: In three independent biofilm-producing, hemagglutination-positive S. epidermidis isolates, interruption of the icaADBC operon essential for polysaccharide intercellular adhesin (PIA) synthesis by Tn917 insertions led to a hemag GLUTination-negative phenotype.
Journal ArticleDOI
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
Welbeck Danquah,Catherine Meyer-Schwesinger,Björn Rissiek,Carolina Pinto,Arnau Serracant-Prat,Miriam Amadi,Domenica Iacenda,Jan-Hendrik Knop,Anna Hammel,Philine Bergmann,Philine Bergmann,Nicole Schwarz,Joana Assuncao,Wendy Rotthier,Friedrich Haag,Eva Tolosa,Peter Bannas,Eric Boué-Grabot,Tim Magnus,Toon Laeremans,Catelijne Stortelers,Friedrich Koch-Nolte +21 more
TL;DR: The results show that nanobody technology can generate potent, specific therapeutics against ion channels, confirm P2x7 as a therapeutic target for inflammatory disorders, and characterize a potent new drug candidate that targets P2X7.
Journal ArticleDOI
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.
Karina Kaczmarek-Hajek,Jiong Zhang,Jiong Zhang,Robin Kopp,Antje Grosche,Antje Grosche,Björn Rissiek,Annika Saul,Santina Bruzzone,Tobias Engel,Tina Jooss,Anna Krautloher,Stefanie Schuster,Tim Magnus,Christine Stadelmann,Swetlana Sirko,Friedrich Koch-Nolte,Volker Eulenburg,Volker Eulenburg,Annette Nicke,Annette Nicke +20 more
TL;DR: This novel mouse model overcomes previous limitations in P2X7 research and will help to determine its physiological roles and contribution to diseases and show potential consequences of its overexpression in ischemic retina and post-traumatic cerebral cortex grey matter.
Journal ArticleDOI
P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
Alazne Zabala,Nuria Vázquez-Villoldo,Björn Rissiek,Jon Gejo,Abraham Martín,Aitor Palomino,Alberto Pérez-Samartín,Krishna R. Pulagam,Marco Lukowiak,Estibaliz Capetillo-Zarate,Estibaliz Capetillo-Zarate,Jordi Llop,Tim Magnus,Friedrich Koch-Nolte,François Rassendren,Carlos Matute,María Domercq +16 more
TL;DR: Evidence that P2X4Rs modulate microglia/macrophage inflammatory responses during autoimmune inflammation is provided and IVM is identified as a potential candidate among currently used drugs to promote the repair of myelin damage.