T
Tim Magnus
Researcher at University of Hamburg
Publications - 154
Citations - 7001
Tim Magnus is an academic researcher from University of Hamburg. The author has contributed to research in topics: Microglia & Inflammation. The author has an hindex of 38, co-authored 133 publications receiving 5338 citations. Previous affiliations of Tim Magnus include Hamburg University of Technology & Eppendorf (Germany).
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Journal ArticleDOI
Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs.
Mattia Gallizioli,Francesc Miró-Mur,Amaia Otxoa-de-Amezaga,Roger Cugota,Angélica Salas-Perdomo,Carles Justicia,Vanessa H Brait,Francisca Ruiz-Jaén,Maria Arbaizar-Rovirosa,Jordi Pedragosa,Ester Bonfill-Teixidor,Mathias Gelderblom,Tim Magnus,Eva Cano,Carlos del Fresno,David Sancho,Anna M. Planas +16 more
TL;DR: It is reported that, after cerebral ischemia, microglia attract DCs to the inflamed brain, and astroglia produce Flt3 ligand, supporting development and expansion of CD11c+ cells.
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Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex
Chengyan Chu,Anna Jablonska,Wojciech G. Lesniak,Aline M. Thomas,Xiaoyan Lan,Raleigh M. Linville,Shen Li,Peter C. Searson,Guanshu Liu,Monica S. Pearl,Martin G. Pomper,Miroslaw Janowski,Tim Magnus,Piotr Walczak,Piotr Walczak +14 more
TL;DR: This study established reproducible cortical OBBBO in mice, which enabled multi-photon microscopy studies on O BBBO and drug targeting and helped demonstrate in a dynamic fashion extravasation of fluorescently-tagged antibodies and their effective delivery into the brain across an osmotically opened BBB.
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Immune activation in amyloid-β-related angiitis correlates with decreased parenchymal amyloid-β plaque load.
S. Bogner,Christian Bernreuther,Jakob Matschke,Alvaro Barrera-Ocampo,Diego Sepulveda-Falla,Frank Leypoldt,Tim Magnus,F. Haag,M. Bergmann,W. Brück,S. Vogelgesang,Markus Glatzel +11 more
TL;DR: Results are in line with the hypothesis of ABRA being the result of an excessive immune response to Aβ and show that this can lead to enhanced clearance of Aβ from the brain parenchyma by immune-mediated mechanisms.
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IL-17 production by CSF lymphocytes as a biomarker for cerebral vasculitis
Vivien Thom,Sabrina Schmid,Mathias Gelderblom,Romy Hackbusch,Manuela Kolster,Simon Schuster,Götz Thomalla,Oliver Keminer,Ole Pleß,Christian Bernreuther,Markus Glatzel,Karl Wegscheider,Christian Gerloff,Tim Magnus,Eva Tolosa +14 more
TL;DR: Intracellular IL-17 in CSF cells is potentially useful in discriminating cerebral vasculitis as a rare cause in patients presenting with ischemic stroke.
Journal ArticleDOI
Therapeutic Potential of Intravenous Immunoglobulin in Acute Brain Injury.
TL;DR: Further insight is given into the role of secondary inflammation in acute brain injury with an emphasis on stroke and the therapeutic potential of IVIg is investigated.