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Timothy C. Y. Chan
Researcher at University of Toronto
Publications - 147
Citations - 3543
Timothy C. Y. Chan is an academic researcher from University of Toronto. The author has contributed to research in topics: Population & Linear programming. The author has an hindex of 27, co-authored 138 publications receiving 2442 citations. Previous affiliations of Timothy C. Y. Chan include St. Michael's GAA, Sligo & Queen's University.
Papers
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Journal ArticleDOI
Accounting for range uncertainties in the optimization of intensity modulated proton therapy.
TL;DR: Two treatment planning concepts for IMPT are presented which incorporate range uncertainties into the optimization, and both yield treatment plans that are considerably less sensitive to range variations compared to conventional treatment plans optimized without accounting for range uncertainties.
Journal ArticleDOI
Optimizing a Drone Network to Deliver Automated External Defibrillators
Justin J. Boutilier,Steven C. Brooks,Alyf Janmohamed,Adam Byers,Jason E. Buick,Cathy Zhan,Angela P. Schoellig,Sheldon Cheskes,Laurie J. Morrison,Timothy C. Y. Chan +9 more
TL;DR: An optimized drone network designed with the aid of a novel mathematical model can substantially reduce the AED delivery time to an out-of-hospital cardiac arrest event.
Journal ArticleDOI
Applications of machine learning algorithms to predict therapeutic outcomes in depression: A meta-analysis and systematic review
Yena Lee,Renee-Marie Ragguett,Rodrigo B. Mansur,Justin J. Boutilier,Joshua D. Rosenblat,Alisson Paulino Trevizol,Elisa Brietzke,Kangguang Lin,Zihang Pan,Mehala Subramaniapillai,Timothy C. Y. Chan,Dominika Fus,Caroline Park,Natalie Musial,Hannah Zuckerman,Vincent Chin-Hung Chen,Roger C.M. Ho,Carola Rong,Roger S. McIntyre +18 more
TL;DR: Machine learning algorithms provide a powerful conceptual and analytic framework capable of integrating multiple data types and sources and may more effectively model neurobiological components as functional modules of pathophysiology embedded within the complex, social dynamics that influence the phenomenology of mental disorders.
Journal ArticleDOI
A new mathematical programming approach to optimize wind farm layouts
TL;DR: In this article, a new mathematical programming approach for wind farm layout optimization is developed, which uses Jensen's wake decay model to represent multi-turbine wake effects and develops mixed integer linear and quadratic optimization formulations.
Journal ArticleDOI
Robust radiotherapy planning.
Jan Unkelbach,Markus Alber,Mark Bangert,Rasmus Bokrantz,Timothy C. Y. Chan,Joseph O. Deasy,Albin Fredriksson,Bram L. Gorissen,Marcel van Herk,Wei Liu,Houra Mahmoudzadeh,Omid Nohadani,Jeffrey V. Siebers,Marnix G. Witte,H Xu +14 more
TL;DR: Robust and probabilistic optimization methods have been developed that directly incorporate motion and uncertainty into treatment plan optimization for intensity modulated radiotherapy (IMRT) andintensity modulated proton therapy (IMPT) and these methods are made available for clinical use.