T
Timothy S. Finco
Researcher at Agnes Scott College
Publications - 18
Citations - 3092
Timothy S. Finco is an academic researcher from Agnes Scott College. The author has contributed to research in topics: Jurkat cells & Signal transduction. The author has an hindex of 13, co-authored 18 publications receiving 3058 citations. Previous affiliations of Timothy S. Finco include University of Georgia & University of California, San Francisco.
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Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.
TL;DR: It is demonstrated that I kappa B alpha is rapidly resynthesized after loss, indicating that an autoregulatory mechanism is involved in the regulation of NF-kappa B function.
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LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway
TL;DR: Reexpression of LAT in J.CaM2 restored all aspects of TCR signaling, demonstrating a necessary and exclusive role for LAT in T cell activation.
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Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis
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Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation
Timothy S. Finco,John Westwick,Jacqueline L. Norris,Amer A. Beg,Channing J. Der,Albert S. Baldwin +5 more
TL;DR: It is shown here that oncogenic forms of Ha-Ras activate NF-κB, not through induced nuclear translocation, but rather through the activation of the transcriptional function of the NF-σκB RelA/p65 subunit.
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Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors
TL;DR: It is demonstrated in this study that protease inhibitors and an additional protease inhibitor also completely repress inducible phosphorylation of I kappa B alpha, suggesting a more complex role of proteases in NF-kappa B activation.