T
Ting Guo
Researcher at Texas A&M University
Publications - 14
Citations - 397
Ting Guo is an academic researcher from Texas A&M University. The author has contributed to research in topics: Proinflammatory cytokine & Adipose tissue. The author has an hindex of 7, co-authored 14 publications receiving 327 citations. Previous affiliations of Ting Guo include Nanjing University.
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Journal ArticleDOI
Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity.
Shih Lung Woo,Hang Xu,Honggui Li,Yan Zhao,Xiang Hu,Xiang Hu,Jiajia Zhao,Jiajia Zhao,Xin Guo,Ting Guo,Rachel Botchlett,Ting Qi,Ya Pei,Juan Zheng,Juan Zheng,Yiming Xu,Xiaofei An,Lulu Chen,Lili Chen,Qifu Li,Xiaoqiu Xiao,Yuqing Huo,Yuqing Huo,Chaodong Wu +23 more
TL;DR: It is suggested that metformin protects against obesity-associated NAFLD largely through direct effects on decreasing hepatocyte fat deposition and on inhibiting inflammatory responses in both hepatocytes and macrophages.
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Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity.
Ting Guo,Shih Lung Woo,Xin Guo,Honggui Li,Juan Zheng,Juan Zheng,Rachel Botchlett,Mengyang Liu,Ya Pei,Hang Xu,Yuli Cai,Yuli Cai,Tianshu Zeng,Lulu Chen,Xiaodong Li,Qifu Li,Xiaoqiu Xiao,Yuqing Huo,Chaodong Wu +18 more
TL;DR: An AMP-activated protein kinase (AMPK)-independent mechanism for BBR to suppress obesity-associated inflammation and improve hepatic steatosis is revealed and actions on improving aspects of NAFLD are largely attributable to BBR suppression of inflammation, which is independent of AMPK.
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Myeloid Cell-specific Disruption of Period1 and Period2 Exacerbates Diet-induced Inflammation and Insulin Resistance
Hang Xu,Honggui Li,Shih Lung Woo,Sam-Moon Kim,Vikram R. Shende,Nichole Neuendorff,Xin Guo,Ting Guo,Ting Qi,Ya Pei,Yan Zhao,Xiang Hu,Jiajia Zhao,Jiajia Zhao,Lili Chen,Lulu Chen,Jun-Yuan Ji,Robert C. Alaniz,David J. Earnest,Chaodong Wu +19 more
TL;DR: Macrophage circadian clock dysregulation is a key process in the physiological cascade by which diet-induced obesity triggers macrophage proinflammatory activation, adipose tissue inflammation, and insulin resistance.
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The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression.
TL;DR: Data indicated for the first time that one of the anti-migrated mechanisms of dexamethasone is due to the induction of PGC-1α expression, which suppresses PDGF-induced VSMC migration through PPARγ coactivation and, consequently, p38 MAPK inhibition.
Journal ArticleDOI
Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation
Xin Guo,Chang Shu,Honggui Li,Ya Pei,Shih Lung Woo,Juan Zheng,Mengyang Liu,Hang Xu,Rachel Botchlett,Ting Guo,Yuli Cai,Xinsheng Gao,Jing Zhou,Lu Chen,Qifu Li,Xiaoqiu Xiao,Linglin Xie,Ke Zhang,Jun-Yuan Ji,Yuqing Huo,Yuqing Huo,Fanyin Meng,Gianfranco Alpini,Pingwei Li,Chaodong Wu +24 more
TL;DR: In obese mice, treatment with cGAMP significantly decreases diet-induced proinflammatory responses in liver and adipose tissues and ameliorates metabolic dysregulation, indicating potential applications of cGamp in treating obesity-associated inflammatory and metabolic diseases.