T
Todd W. Geders
Researcher at University of Minnesota
Publications - 17
Citations - 1192
Todd W. Geders is an academic researcher from University of Minnesota. The author has contributed to research in topics: Polyketide synthase & Polyketide. The author has an hindex of 16, co-authored 17 publications receiving 1088 citations. Previous affiliations of Todd W. Geders include Purdue University & Life Sciences Institute.
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Journal ArticleDOI
Lewis Acid Mediated Hydrosilylation on Porous Silicon Surfaces
Jillian M. Buriak,Michael P. Stewart,Todd W. Geders,Matthew J. Allen,Hee Cheul Choi,Jay Smith,Daniel Raftery,Leigh T. Canham +7 more
TL;DR: In this article, Lewis acid mediated hydrosilylation of alkynes and alkenes on non-oxidized hydride-terminated porous silicon derivatizes the surface with alkenyl and alkyl functionalities, respectively.
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Metamorphic enzyme assembly in polyketide diversification
Liangcai Gu,Bo Wang,Amol Kulkarni,Todd W. Geders,Rashel V. Grindberg,Lena Gerwick,Kristina Håkansson,Peter Wipf,Janet L. Smith,William H. Gerwick,David H. Sherman,David H. Sherman +11 more
TL;DR: The combination of chlorination and polyketide β-branching, coupled with mechanistic diversification of ECH2 and enoyl reductase, leads to the formation of cyclopropane and vinyl chloride moieties.
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GNAT-Like Strategy for Polyketide Chain Initiation
Liangcai Gu,Todd W. Geders,Bo Wang,William H. Gerwick,Kristina Håkansson,Janet L. Smith,David H. Sherman +6 more
TL;DR: An unexpected biochemical strategy for chain initiation is described for the loading module of the polyketide synthase of curacin A, an anticancer lead derived from the marine cyanobacterium Lyngbya majuscula.
Journal ArticleDOI
Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.
Tonia J. Buchholz,Todd W. Geders,Frank E. Bartley,Kevin A. Reynolds,Janet L. Smith,David H. Sherman +5 more
TL;DR: A comprehensive analysis of the binding affinity and selectivity for the complete set of discrete docking domain pairs in the pikromycin and erythromycin PKS systems is reported, finding that each cognate pair of docking domains retained exquisite binding selectivity.
Journal ArticleDOI
Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis
Benjamin P. Duckworth,Todd W. Geders,Divya Tiwari,Helena I. Boshoff,Paul A. Sibbald,Clifton E. Barry,Dirk Schnappinger,Barry C. Finzel,Courtney C. Aldrich +8 more
TL;DR: The design, development, and evaluation of a rationally designed bisubstrate inhibitor of MtBPL are described, showing that the inhibitor decreases in vivo protein biotinylation of key enzymes involved in fatty acid biosynthesis and that the antibacterial activity is MtB PL dependent.