T
Tokiko Watanabe
Researcher at University of Tokyo
Publications - 91
Citations - 10611
Tokiko Watanabe is an academic researcher from University of Tokyo. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 42, co-authored 86 publications receiving 9344 citations. Previous affiliations of Tokiko Watanabe include Osaka University & University of Wisconsin-Madison.
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Journal ArticleDOI
Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques.
Maki Kiso,Kiyoko Iwatsuki-Horimoto,Seiya Yamayoshi,Ryuta Uraki,Mutsumi Ito,Noriko Nakajima,Shinya Yamada,Masaki Imai,Eiryo Kawakami,Yuriko Tomita,Satoshi Fukuyama,Yasushi Itoh,Kazumasa Ogasawara,Tiago J. S. Lopes,Tiago J. S. Lopes,Tokiko Watanabe,Louise H. Moncla,Hideki Hasegawa,Thomas C. Friedrich,Gabriele Neumann,Yoshihiro Kawaoka,Yoshihiro Kawaoka +21 more
TL;DR: Oseltamivir treatment at 2 different doses reduced A(H7N9) viral titers in infected animals, but even high-dose oseltAMivir did not block viral replication sufficiently to suppress the emergence of resistant variants.
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The host protein CLUH participates in the subnuclear transport of influenza virus ribonucleoprotein complexes.
Tomomi Ando,Seiya Yamayoshi,Yuriko Tomita,Shinji Watanabe,Tokiko Watanabe,Yoshihiro Kawaoka,Yoshihiro Kawaoka +6 more
TL;DR: CLUH depletion inhibited the translocation of M1 to SC35-positive speckles, but did not interfere with PB2 localization to the nucleoplasm and disrupted the subnuclear transport of vRNP, abolishing vR NP nuclear export without affecting viral RNA or protein expression.
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Co-administration of Favipiravir and the Remdesivir Metabolite GS-441524 Effectively Reduces SARS-CoV-2 Replication in the Lungs of the Syrian Hamster Model
Shiho Chiba,Maki Kiso,Noriko Nakajima,Shun Iida,Tadashi Maemura,Makoto Kuroda,Yuko Sato,Mutsumi Ito,Moe Okuda,Shinya Yamada,Kiyoko Iwatsuki-Horimoto,Tokiko Watanabe,Masaki Imai,Tammy Armbrust,Ralph S. Baric,Peter Halfmann,Tadaki Suzuki,Yoshihiro Kawaoka +17 more
TL;DR: Co-administration of favipiravir and the remdesivir metabolite GS-441524 more effectively blocked SARS-CoV-2 replication in the lungs of Syrian hamsters than either favipIRavir or GS- 441524 alone as part of a prophylactic or therapeutic regimen.
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Identification of a distinct lineage of aviadenovirus from crane feces
Yahiro Mukai,Yuriko Tomita,Kirill Kryukov,So Nakagawa,Makoto Ozawa,Makoto Ozawa,Tsutomu Matsui,Keizo Tomonaga,Tadashi Imanishi,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Tokiko Watanabe,Masayuki Horie +12 more
TL;DR: Results of this study contribute to a deeper understanding of the diversity and evolution of viruses and provide additional information on viruses that infect cranes, which might lead to protection of the endangered species of cranes.
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Serological analysis of Ebola virus survivors and close contacts in Sierra Leone: A cross-sectional study.
Peter Halfmann,Amie J. Eisfeld,Tokiko Watanabe,Tadashi Maemura,Makoto Yamashita,Satoshi Fukuyama,Tammy Armbrust,Isaiah Rozich,Alhaji U. N’jai,Alhaji U. N’jai,Gabriele Neumann,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Foday Sahr +13 more
TL;DR: The antibody levels in survivors and the seroconversion in close contacts who took care of Ebola-infected individuals, but did not develop symptoms of Ebola virus disease are examined to determine whether these close contacts truly experienced subclinical infections and whether these asymptomatic infections played a role in the dynamics of transmission.