M
Makoto Yamashita
Researcher at University of Tokyo
Publications - 22
Citations - 1829
Makoto Yamashita is an academic researcher from University of Tokyo. The author has contributed to research in topics: Virus & Neuraminidase. The author has an hindex of 10, co-authored 22 publications receiving 1680 citations. Previous affiliations of Makoto Yamashita include Daiichi Sankyo.
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Journal ArticleDOI
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Yasushi Itoh,Kyoko Shinya,Maki Kiso,Tokiko Watanabe,Yoshihiro Sakoda,Masato Hatta,Yukiko Muramoto,Daisuke Tamura,Yuko Sakai-Tagawa,Takeshi Noda,Saori Sakabe,Masaki Imai,Yasuko Hatta,Shinji Watanabe,Chengjun Li,Shinya Yamada,Ken Fujii,Shin Murakami,Hirotaka Imai,Satoshi Kakugawa,Mutsumi Ito,Ryo Takano,Kiyoko Iwatsuki-Horimoto,Masayuki Shimojima,Taisuke Horimoto,Hideo Goto,Kei Takahashi,Akiko Makino,Hirohito Ishigaki,Misako Nakayama,Masatoshi Okamatsu,Kazuo Takahashi,David Warshauer,Peter A. Shult,Reiko Saito,Hiroshi Suzuki,Yousuke Furuta,Makoto Yamashita,Keiko Mitamura,Kunio Nakano,Morio Nakamura,Rebecca A. Brockman-Schneider,Hiroshi Mitamura,Masahiko Yamazaki,Norio Sugaya,M. Suresh,Makoto Ozawa,Makoto Ozawa,Gabriele Neumann,James E. Gern,Hiroshi Kida,Kazumasa Ogasawara,Yoshihiro Kawaoka +52 more
TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.
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Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development
Tokiko Watanabe,Eiryo Kawakami,Jason E. Shoemaker,Tiago J. S. Lopes,Yukiko Matsuoka,Yuriko Tomita,Hiroko Kozuka-Hata,Takeo Gorai,Tomoko Kuwahara,Eiji Takeda,Atsushi Nagata,Ryo Takano,Maki Kiso,Makoto Yamashita,Yuko Sakai-Tagawa,Hiroaki Katsura,Naoki Nonaka,Hiroko Fujii,Ken Fujii,Yukihiko Sugita,Takeshi Noda,Hideo Goto,Satoshi Fukuyama,Shinji Watanabe,Gabriele Neumann,Masaaki Oyama,Hiroaki Kitano,Yoshihiro Kawaoka +27 more
TL;DR: A network of virus-host protein interactions based on the stage of the viral life cycle affected upon host factor downregulation is generated and several proteins, notably Golgi-specific brefeldin A-resistant guanine nucleotide exchange factor 1 and JAK1, are validated as potential antiviral drug targets.
Journal ArticleDOI
A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets
Masaki Imai,Tokiko Watanabe,Maki Kiso,Noriko Nakajima,Seiya Yamayoshi,Kiyoko Iwatsuki-Horimoto,Masato Hatta,Shinya Yamada,Mutsumi Ito,Yuko Sakai-Tagawa,Masayuki Shirakura,Emi Takashita,Seiichiro Fujisaki,Ryan McBride,Andrew J. Thompson,Kenta Takahashi,Tadashi Maemura,Hiromichi Mitake,Shiho Chiba,Gongxun Zhong,Shufang Fan,Kohei Oishi,Atsuhiro Yasuhara,Kosuke Takada,Tomomi Nakao,Satoshi Fukuyama,Makoto Yamashita,Tiago J. S. Lopes,Tiago J. S. Lopes,Gabriele Neumann,Takato Odagiri,Shinji Watanabe,Yuelong Shu,James C. Paulson,Hideki Hasegawa,Yoshihiro Kawaoka,Yoshihiro Kawaoka +36 more
TL;DR: The results suggest that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored.
Journal ArticleDOI
Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets.
Masaki Imai,Makoto Yamashita,Yuko Sakai-Tagawa,Kiyoko Iwatsuki-Horimoto,Maki Kiso,Jurika Murakami,Atsuhiro Yasuhara,Kosuke Takada,Mutsumi Ito,Noriko Nakajima,Kenta Takahashi,Tiago J. S. Lopes,Tiago J. S. Lopes,Jayeeta Dutta,Zenab Khan,Divya Kriti,Harm van Bakel,Akifumi Tokita,Haruhisa Hagiwara,Naomi Izumida,Haruo Kuroki,Tamon Nishino,Noriyuki Wada,Michiko Koga,Eisuke Adachi,Daisuke Jubishi,Hideki Hasegawa,Yoshihiro Kawaoka,Yoshihiro Kawaoka +28 more
TL;DR: It is reported that resistant viruses isolated from Japanese patients have normal replicative abilities and pathogenicity in animal models and thus might spread in humans.
Journal ArticleDOI
Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses.
Maki Kiso,Kyoko Shinya,Masayuki Shimojima,Ryo Takano,Kei Takahashi,Hiroaki Katsura,Satoshi Kakugawa,Mai thi Quynh Le,Makoto Yamashita,Yousuke Furuta,Makoto Ozawa,Makoto Ozawa,Yoshihiro Kawaoka +12 more
TL;DR: In this article, the authors characterized in vitro and in vivo properties of two pairs of oseltaimivir-sensitive and -resistant (possessing the NA H274Y substitution) 2009 H1N1 pandemic viruses isolated in different parts of the world.