M
Maki Kiso
Researcher at University of Tokyo
Publications - 96
Citations - 9783
Maki Kiso is an academic researcher from University of Tokyo. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 33, co-authored 73 publications receiving 7875 citations.
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Journal ArticleDOI
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
Masaki Imai,Tokiko Watanabe,Masato Hatta,Subash C. Das,Makoto Ozawa,Makoto Ozawa,Kyoko Shinya,Gongxun Zhong,Anthony Hanson,Hiroaki Katsura,Shinji Watanabe,Chengjun Li,Eiryo Kawakami,Shinya Yamada,Maki Kiso,Yasuo Suzuki,Eileen A. Maher,Gabriele Neumann,Yoshihiro Kawaoka +18 more
TL;DR: Results indicate that H5 HA can convert to an HA that supports efficient viral transmission in mammals, and will help individuals conducting surveillance in regions with circulating H5N1 viruses to recognize key residues that predict the pandemic potential of isolate, which will inform the development, production and distribution of effective countermeasures.
Journal ArticleDOI
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Yasushi Itoh,Kyoko Shinya,Maki Kiso,Tokiko Watanabe,Yoshihiro Sakoda,Masato Hatta,Yukiko Muramoto,Daisuke Tamura,Yuko Sakai-Tagawa,Takeshi Noda,Saori Sakabe,Masaki Imai,Yasuko Hatta,Shinji Watanabe,Chengjun Li,Shinya Yamada,Ken Fujii,Shin Murakami,Hirotaka Imai,Satoshi Kakugawa,Mutsumi Ito,Ryo Takano,Kiyoko Iwatsuki-Horimoto,Masayuki Shimojima,Taisuke Horimoto,Hideo Goto,Kei Takahashi,Akiko Makino,Hirohito Ishigaki,Misako Nakayama,Masatoshi Okamatsu,Kazuo Takahashi,David Warshauer,Peter A. Shult,Reiko Saito,Hiroshi Suzuki,Yousuke Furuta,Makoto Yamashita,Keiko Mitamura,Kunio Nakano,Morio Nakamura,Rebecca A. Brockman-Schneider,Hiroshi Mitamura,Masahiko Yamazaki,Norio Sugaya,M. Suresh,Makoto Ozawa,Makoto Ozawa,Gabriele Neumann,James E. Gern,Hiroshi Kida,Kazumasa Ogasawara,Yoshihiro Kawaoka +52 more
TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.
Journal ArticleDOI
Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.
Masaki Imai,Kiyoko Iwatsuki-Horimoto,Masato Hatta,Samantha Loeber,Peter Halfmann,Noriko Nakajima,Tokiko Watanabe,Michiko Ujie,Kenta Takahashi,Mutsumi Ito,Shinya Yamada,Shufang Fan,Shiho Chiba,Makoto Kuroda,Lizheng Guan,Kosuke Takada,Tammy Armbrust,Aaron Balogh,Yuri Furusawa,Moe Okuda,Hiroshi Ueki,Atsuhiro Yasuhara,Yuko Sakai-Tagawa,Tiago J. S. Lopes,Tiago J. S. Lopes,Maki Kiso,Seiya Yamayoshi,Noriko Kinoshita,Norio Ohmagari,Shin-ichiro Hattori,Makoto Takeda,Hiroaki Mitsuya,Florian Krammer,Tadaki Suzuki,Yoshihiro Kawaoka,Yoshihiro Kawaoka +35 more
TL;DR: It is found that SARS-CoV-2 isolates replicate efficiently in the lungs of Syrian hamsters and cause severe pathological lesions in the lung of these animals similar to commonly reported imaging features of COVID-19 patients with pneumonia.
Journal ArticleDOI
Resistant influenza A viruses in children treated with oseltamivir: descriptive study
Maki Kiso,Keiko Mitamura,Yuko Sakai-Tagawa,Kyoko Shiraishi,Chiharu Kawakami,Kazuhiro Kimura,Frederick G. Hayden,Norio Sugaya,Yoshihiro Kawaoka,Yoshihiro Kawaoka +9 more
TL;DR: Sensitivity testing to oseltamivir carboxylate revealed that the neuraminidases of viruses that have an Arg292Lys, Glu119Val, or Asn294Ser mutation were about 10(4)-10(5)-fold, 500-fold, or 300-fold more resistant than their pretreatment neuraminIDases, respectively.
Journal ArticleDOI
Avian flu: isolation of drug-resistant H5N1 virus.
Q. Mai Le,Maki Kiso,Kazuhiko Someya,Yuko T. Sakai,T. Hien Nguyen,Khan H. L. Nguyen,N. Dinh Pham,Ha H. Ngyen,Shinya Yamada,Yukiko Muramoto,Taisuke Horimoto,Ayato Takada,Hideo Goto,Takashi Suzuki,Yasuo Suzuki,Yoshihiro Kawaoka +15 more
TL;DR: The isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza is reported.