Institution
University of Sierra Leone
Education•Freetown, Sierra Leone•
About: University of Sierra Leone is a education organization based out in Freetown, Sierra Leone. It is known for research contribution in the topics: Sierra leone & Population. The organization has 484 authors who have published 598 publications receiving 11692 citations.
Topics: Sierra leone, Population, Health care, Public health, Ebola virus
Papers published on a yearly basis
Papers
More filters
••
Harvard University1, Boston Children's Hospital2, King's College London3, Lund University4, Massachusetts Eye and Ear Infirmary5, University of São Paulo6, University of California, San Diego7, Imperial College London8, Brigham and Women's Hospital9, Partners In Health10, Royal North Shore Hospital11, Medical College of Wisconsin12, Monash University13, Nanyang Technological University14, University of Sierra Leone15, University of Oxford16, Mongolian National University17, University of Malawi18, Flinders University19, Beth Israel Deaconess Medical Center20, Bhabha Atomic Research Centre21, Royal Australasian College of Surgeons22, Stanford University23, University of California, San Francisco24
TL;DR: The need for surgical services in low- and middleincome countries will continue to rise substantially from now until 2030, with a large projected increase in the incidence of cancer, road traffic injuries, and cardiovascular and metabolic diseases in LMICs.
2,209 citations
••
TL;DR: This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources.
Abstract: In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to characterize patterns of viral transmission over the initial weeks of the epidemic. This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.
1,164 citations
••
Innovations for Poverty Action1, Wageningen University and Research Centre2, National Research University – Higher School of Economics3, Columbia University4, Yale University5, University of Lagos6, Institute for Fiscal Studies7, Universidade Nova de Lisboa8, Lahore University of Management Sciences9, University of St Andrews10, Stockholm School of Economics11, Ghent University12, Alternatives13, Trinity College, Dublin14, University of Sierra Leone15, Kathmandu16, Cornell University17, University of Illinois at Chicago18, New York University Abu Dhabi19, Princeton University20, Stockholm University21, Tufts University22, University of Michigan23, Northwestern University24, London School of Economics and Political Science25
TL;DR: In this article, the authors analyzed COVID-19 vaccine acceptance across 15 survey samples covering 10 low and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals.
Abstract: Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals. We find considerably higher willingness to take a COVID-19 vaccine in our LMIC samples (mean 80.3%; median 78%; range 30.1 percentage points) compared with the United States (mean 64.6%) and Russia (mean 30.4%). Vaccine acceptance in LMICs is primarily explained by an interest in personal protection against COVID-19, while concern about side effects is the most common reason for hesitancy. Health workers are the most trusted sources of guidance about COVID-19 vaccines. Evidence from this sample of LMICs suggests that prioritizing vaccine distribution to the Global South should yield high returns in advancing global immunization coverage. Vaccination campaigns should focus on translating the high levels of stated acceptance into actual uptake. Messages highlighting vaccine efficacy and safety, delivered by healthcare workers, could be effective for addressing any remaining hesitancy in the analyzed LMICs.
536 citations
••
University of Edinburgh1, Fred Hutchinson Cancer Research Center2, University of Southampton3, Katholieke Universiteit Leuven4, University of Oxford5, Broad Institute6, United States Department of the Army7, Technical University of Denmark8, University of Cambridge9, Wellcome Trust Sanger Institute10, Erasmus University Rotterdam11, Bernhard Nocht Institute for Tropical Medicine12, Public Health England13, Pasteur Institute14, University of Sierra Leone15, Harvard University16, University of Liverpool17, University of Makeni18, University of Bristol19, University of Birmingham20, Princeton University21, Centre national de la recherche scientifique22, Louisiana State University23, Scripps Health24, Scripps Research Institute25, World Health Organization26, Chinese Center for Disease Control and Prevention27, University of Sydney28, Imperial College London29, National Institutes of Health30, Centers for Disease Control and Prevention31, University of California, Los Angeles32
TL;DR: It is revealed that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity, which will help to inform interventions in future epidemics.
Abstract: The 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.
354 citations
••
Broad Institute1, University of Edinburgh2, Harvard University3, National Center for Immunization and Respiratory Diseases4, Scripps Research Institute5, Massachusetts Institute of Technology6, United States Department of the Army7, Tulane University8, National Institutes of Health9, Médecins Sans Frontières10, Cheikh Anta Diop University11, University of Sierra Leone12, University of Sydney13, Fred Hutchinson Cancer Research Center14
TL;DR: Analysis of sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic, confirms sustained human-to-human transmission within Sierra Leone and finds no evidence for import or export of EBOV across national borders after its initial introduction.
275 citations
Authors
Showing all 493 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen J. Culver | 43 | 164 | 5031 |
Peter James | 36 | 181 | 10700 |
Maurice E. Tucker | 34 | 42 | 8004 |
Janette E. Bradley | 33 | 103 | 3616 |
Osman Sankoh | 32 | 108 | 9596 |
Temidayo O. Ogundiran | 30 | 84 | 2902 |
David Griffiths | 25 | 51 | 1960 |
Thaim B. Kamara | 24 | 74 | 3526 |
Marcy Winget | 23 | 81 | 4677 |
Foday Sahr | 22 | 85 | 2010 |
Albert Samà | 21 | 43 | 1424 |
Mohamed Samai | 15 | 37 | 899 |
Ogunlade Davidson | 15 | 24 | 16058 |
N. Singh | 15 | 42 | 895 |
Haja Wurie | 14 | 45 | 795 |