T
Tom Doherty
Researcher at Medical Research Council
Publications - 31
Citations - 2524
Tom Doherty is an academic researcher from Medical Research Council. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 21, co-authored 31 publications receiving 2441 citations. Previous affiliations of Tom Doherty include University of London & University College London.
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Journal ArticleDOI
Efficacy of RTS, S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial
Kalifa Bojang,Paul Milligan,Margaret Pinder,Laurence Vigneron,Ali Alloueche,Kent E. Kester,W. Ripley Ballou,David J. Conway,William H. H. Reece,Philip Gothard,Lawrence Yamuah,Martine Delchambre,Gerald Voss,Brian Greenwood,Adrian V. S. Hill,Keith P. W. J. McAdam,Nadia Tornieporth,Joe Cohen,Tom Doherty +18 more
TL;DR: RTS,S/AS02 is safe, immunogenic, and is the first pre-erythrocytic vaccine to show significant protection against natural P. falciparum infection in semi-immune adult men in The Gambia.
Journal ArticleDOI
A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.
William H. H. Reece,Margaret Pinder,Philip Gothard,Paul Milligan,Kalifa Bojang,Tom Doherty,Magdalena Plebanski,Peter Akinwunmi,Simone Everaere,Katherine R Watkins,Gerald Voss,Nadia Tornieporth,Ali Alloueche,Brian Greenwood,Kent E. Kester,Keith P. W. J. McAdam,Joe Cohen,Adrian V. S. Hill +17 more
TL;DR: A peptide-specific T-cell assay that is strongly associated with protection of humans in The Gambia, West Africa, from both malaria infection and disease is reported, providing direct evidence for a protective role for CD4+ T cells in humans.
Journal ArticleDOI
Artesunate Reduces but Does Not Prevent Posttreatment Transmission of Plasmodium falciparum to Anopheles gambiae
Geoffrey A. T. Targett,Chris Drakeley,Musa Jawara,Lorenz von Seidlein,Rosalind Coleman,J L Deen,Margaret Pinder,Tom Doherty,Tom Doherty,Colin J. Sutherland,Gijs Walraven,Paul Milligan +11 more
TL;DR: Questions are raised about any policy to use pyrimethamine-sulfadoxine alone as the first-line treatment for malaria, and the effect of such therapy on transmission is examined.
Journal Article
Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial (vol 355, pg 352, 2000)
L von Seidlein,Paul Milligan,Margaret Pinder,Kalifa Bojang,C Anyalebechi,Roly Gosling,R. Coleman,J I Ude,A.D. Sadiq,Manoj T. Duraisingh,D. C. Warhurst,Ali Alloueche,G. A. T. Targett,Keith P. W. J. McAdam,Brian Greenwood,G. Walraven,P Olliaoro,Tom Doherty +17 more
TL;DR: The addition of artesunate to malaria treatment regimens in Africa results in lower gametocyte rates and may lower transmission rates, and there was no additional benefit for three doses of artESunate over one dose.
Journal ArticleDOI
Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial
L von Seidlein,Paul Milligan,Margaret Pinder,Kalifa Bojang,C Anyalebechi,Roly Gosling,R. Coleman,J I Ude,A.D. Sadiq,Manoj T. Duraisingh,David C. Warhurst,Ali Alloueche,G. A. T. Targett,Keith P. W. J. McAdam,Brian Greenwood,G. Walraven,Piero Olliaro,Tom Doherty +17 more
TL;DR: The use of artesunate in combination with pyrimethamine-sulphadoxine may delay or prevent resistance in sub-Sharan Africa.