K
Keith P. W. J. McAdam
Researcher at University of London
Publications - 177
Citations - 15056
Keith P. W. J. McAdam is an academic researcher from University of London. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 66, co-authored 175 publications receiving 14581 citations. Previous affiliations of Keith P. W. J. McAdam include Institut de recherche pour le développement & Medical Research Council.
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Journal ArticleDOI
Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial
Felicity T. Cutts,Syed M. A. Zaman,Godwin Enwere,Shabbar Jaffar,Orin S. Levine,Orin S. Levine,J. B. Okoko,Claire Oluwalana,Adeola Vaughan,Steven Obaro,Amanda Leach,Keith P. W. J. McAdam,Ekow Biney,Mark Saaka,U. Onwuchekwa,Fred G. Yallop,Nathaniel F. Pierce,Brian Greenwood,Richard A. Adegbola +18 more
TL;DR: Pneumococcal conjugate vaccine has high efficacy against radiological pneumonia and invasive pneumococcal disease, and can substantially reduce admissions and improve child survival in this rural African setting.
Journal ArticleDOI
Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.
Richard Bellamy,Cyril Ruwende,Tumani Corrah,Keith P. W. J. McAdam,Hilton Whittle,Adrian V. S. Hill +5 more
TL;DR: Genetic variation in NRAMP1 affects susceptibility to tuberculosis in West Africans, and subjects who were heterozygous for twoNRAMP1 polymorphisms in intron 4 and the 3' untranslated region of the gene were particularly overrepresented among those with tuberculosis.
Journal ArticleDOI
Efficacy of RTS, S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial
Kalifa Bojang,Paul Milligan,Margaret Pinder,Laurence Vigneron,Ali Alloueche,Kent E. Kester,W. Ripley Ballou,David J. Conway,William H. H. Reece,Philip Gothard,Lawrence Yamuah,Martine Delchambre,Gerald Voss,Brian Greenwood,Adrian V. S. Hill,Keith P. W. J. McAdam,Nadia Tornieporth,Joe Cohen,Tom Doherty +18 more
TL;DR: RTS,S/AS02 is safe, immunogenic, and is the first pre-erythrocytic vaccine to show significant protection against natural P. falciparum infection in semi-immune adult men in The Gambia.
Journal ArticleDOI
Tuberculosis and Chronic Hepatitis B Virus Infection in Africans and Variation in the Vitamin D Receptor Gene
R. Bellamy,C Ruwende,Tumani Corrah,Keith P. W. J. McAdam,Mark Thursz,H. C. Whittle,A. V. S. Hill +6 more
TL;DR: Variation in the vitamin D receptor gene was typed in 2015 subjects from large case-control studies of three major infectious diseases: tuberculosis, malaria, and hepatitis B virus, and homozygotes for a polymorphism at codon 352 (genotype tt) were significantly underrepresented.
Journal Article
Newborns Develop a Th1-Type Immune Response to Mycobacterium bovis Bacillus Calmette-Guérin Vaccination
Arnaud Marchant,Tessa Goetghebuer,Martin O. C. Ota,Ingrid Wolfe,Serign J. Ceesay,Donat De Groote,Tumani Corrah,Steve Bennett,J. G. Wheeler,Kris Huygen,Peter Aaby,Keith P. W. J. McAdam,Melanie J. Newport +12 more
TL;DR: It is found that BCG vaccination at birth induces a memory Th1-type response of similar magnitude to that when given later in life.