T
Tom Sexton
Researcher at University of Strasbourg
Publications - 46
Citations - 4856
Tom Sexton is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Chromatin & Chromosome conformation capture. The author has an hindex of 17, co-authored 37 publications receiving 4264 citations. Previous affiliations of Tom Sexton include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome
Tom Sexton,Eitan Yaffe,Ephraim Kenigsberg,Frédéric Bantignies,Benjamin Leblanc,Michael Hoichman,Hugues Parrinello,Amos Tanay,Giacomo Cavalli +8 more
TL;DR: A high-resolution chromosomal contact map derived from a modified genome-wide chromosome conformation capture approach applied to Drosophila embryonic nuclei is presented, laying the foundation for detailed studies of chromosome structure and function in a genetically tractable system.
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Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Stefan Schoenfelder,Tom Sexton,Lyubomira Chakalova,Nathan F. Cope,Alice Horton,Simon Andrews,Sreenivasulu Kurukuti,Jennifer A. Mitchell,David Umlauf,Daniela S. Dimitrova,Christopher H. Eskiw,Yanquan Luo,Chia-Lin Wei,Yijun Ruan,James J. Bieker,Peter Fraser +15 more
TL;DR: The first genome-wide analysis of transcriptional interactions using the mouse globin genes in erythroid tissues reveals extensive and preferential intra- and interchromosomal transcription interactomes, establishing a new gene expression paradigm.
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Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus
Suzana Hadjur,Luke Williams,Natalie K. Ryan,Bradley S. Cobb,Tom Sexton,Peter Fraser,Amanda G. Fisher,Matthias Merkenschlager +7 more
TL;DR: It is shown that cohesin forms the topological and mechanistic basis for cell-type-specific long-range chromosomal interactions in cis at the developmentally regulated cytokine locus IFNG and is used not only for the purpose of sister chromatid cohesion, but also to dynamically define the spatial conformation of specific loci.
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The Role of Chromosome Domains in Shaping the Functional Genome
Tom Sexton,Giacomo Cavalli +1 more
TL;DR: The current understanding of how these functional genomic "secondary and tertiary structures" form a blueprint for global nuclear architecture and the potential they hold for understanding and manipulating genomic regulation are described.
Journal ArticleDOI
Gene regulation through nuclear organization
TL;DR: This review highlights mechanistic links between gene position, repression and transcription in the nucleus, and suggests that architectural features have multiple functions that depend upon organization into dedicated subcompartments enriched for distinct enzymatic machinery.