T
Tom Sexton
Researcher at University of Strasbourg
Publications - 46
Citations - 4856
Tom Sexton is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Chromatin & Chromosome conformation capture. The author has an hindex of 17, co-authored 37 publications receiving 4264 citations. Previous affiliations of Tom Sexton include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains
Vuthy Ea,Tom Sexton,Thierry Gostan,Laurie Herviou,Marie-Odile Baudement,Yunzhe Zhang,Soizik Berlivet,Marie-Noëlle Le Lay-Taha,Guy Cathala,Guy Cathala,Annick Lesne,Annick Lesne,Jean-Marc Victor,Jean-Marc Victor,Yuhong Fan,Giacomo Cavalli,Giacomo Cavalli,Thierry Forné,Thierry Forné +18 more
TL;DR: Models issued from polymer physics can accurately describe the organization principles governing chromatin dynamics in both mouse and Drosophila TADs, however, constraints applied on this dynamics within mammalian T ADs have a peculiar impact resulting in a statistical helix organization.
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Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus
Tiegh Taylor,Natalia Sikorska,Virlana M. Shchuka,Sanjay Chahar,Chenfan Ji,Neil Macpherson,Sakthi D Moorthy,Marit A C de Kort,Shanelle Mullany,Nawrah Khader,Zoe E Gillespie,Lida Langroudi,Ian C. Tobias,Tineke L. Lenstra,Jennifer A. Mitchell,Tom Sexton +15 more
TL;DR: A striking disconnection between transcriptional control and chromatin architecture is found and nearly all Sox2 transcriptional activation is traced to a small number of key transcription factor binding sites, whose deletions have no effect on promoter–enhancer interaction frequencies or topological domain organization.
Journal ArticleDOI
Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice
Rafael Alcalá-Vida,Rafael Alcalá-Vida,Jonathan Seguin,Jonathan Seguin,Caroline Lotz,Caroline Lotz,Anne Molitor,Ibai Irastorza-Azcarate,Ali Awada,Ali Awada,Nezih Karasu,Aurélie Bombardier,Aurélie Bombardier,Brigitte Cosquer,Brigitte Cosquer,José Luis Gómez Skarmeta,Jean-Christophe Cassel,Jean-Christophe Cassel,Anne-Laurence Boutillier,Anne-Laurence Boutillier,Tom Sexton,Karine Merienne,Karine Merienne +22 more
TL;DR: In this paper, the authors used a slowly progressing knockin mouse model to profile the HD striatal chromatin landscape at two early disease stages and found that the HD mutation, a CAG expansion in the Htt gene, locally impairs the spatial chromatin organization and proximal gene regulation.
Journal ArticleDOI
Myod1 and GR coordinate myofiber-specific transcriptional enhancers.
D. Rovito,Anna-Isavella Rerra,Vanessa Ueberschlag-Pitiot,Shilpy Joshi,Nezih Karasu,Vanessa Dacleu-Siewe,Khalil Ben Rayana,Kamar Ghaibour,Maxime Parisotto,Arnaud Ferry,Scott A. Jelinsky,Gilles Laverny,Bruno P. Klaholz,Tom Sexton,Isabelle M. L. Billas,Delphine Duteil,Daniel Metzger +16 more
TL;DR: In this paper, the authors investigated the skeletal muscle transcriptional program and identified key tissue-specific regulatory genetic elements, such as Myod1, GR and Nrf1, for myofiber size regulation.
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Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL
Marie Passet,Rathana Kim,Stéphanie Gachet,François Sigaux,Julie Chaumeil,Ava Galland,Tom Sexton,Samuel Quentin,Luis Hernández,Lise Larcher,Hugo Bergugnat,Tao Ye,Nezih Karasu,Aurélie Caye-Eude,Beate Heizmann,Isabelle Duluc,Patrice Chevallier,Philippe Rousselot,Françoise Huguet,Thibaut Leguay,Mathilde Hunault-Berger,Françoise Pflumio,Jean-Noël Freund,Camille Lobry,Véronique Lhéritier,Hervé Dombret,Claire Domon-Dell,Jean Soulier,Nicolas Boissel,Emmanuelle Clappier +29 more
TL;DR: A novel genetic subtype of B-progenitor acute lymphoblastic leukemia characterized by 2 separate focal genomic deletions leading to upregulation of CDX2 on chromosome 13 and to the formation of a chimeric gene fusion (UBTF::ATXN7L3) on chromosome 17 is described.