T
Tom Van Belle
Researcher at Katholieke Universiteit Leuven
Publications - 26
Citations - 2198
Tom Van Belle is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Immune system & CD8. The author has an hindex of 18, co-authored 26 publications receiving 1993 citations. Previous affiliations of Tom Van Belle include Flanders Institute for Biotechnology & The Catholic University of America.
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Journal ArticleDOI
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
TL;DR: The genetic, environmental, and immunological data underlying the prevention and intervention strategies to constrain T1D are explained, including the efficacy of antigen-specific and antigen-nonspecific immune interventions.
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Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice
Tatiana Takiishi,Hannelie Korf,Tom Van Belle,Sofie Robert,Fabio Arturo Grieco,Silvia Caluwaerts,Letizia Galleri,Isabella Spagnuolo,Lothar Steidler,Karolien Van Huynegem,Pieter Demetter,Clive Wasserfall,Mark A. Atkinson,Francesco Dotta,Pieter Rottiers,Conny Gysemans,Chantal Mathieu +16 more
TL;DR: It is shown that combination therapy with low-dose systemic anti-CD3 stably reverted diabetes in NOD mice and increased frequencies of local Tregs, which not only accumulated in the pancreatic islets, but also suppressed immune response in an autoantigen-specific way, allowing reversal of established autoimmune diabetes.
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Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice
Andrew P. R. Sutherland,Tom Van Belle,Andrea L. Wurster,Akira Suto,Monia Michaud,Dorothy Zhang,Michael J. Grusby,Matthias von Herrath +7 more
TL;DR: This work provides demonstration of the essential prodiabetogenic activities of IL-21 on diverse genetic backgrounds (NOD and C57BL/6) and indicates that IL- 21 blockade could be a promising strategy for interventions in human type 1 diabetes.
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Vitamin D in autoimmune, infectious and allergic diseases: a vital player?
TL;DR: The genetic and epidemiologic data potentially linking vitamin D to autoimmune, infectious and allergic diseases are summarized and how vitamin D influences the immune responses in each of those conditions is discussed based on the data generated using patient samples or preclinical models of each of these diseases.
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Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice
Sofie Robert,Conny Gysemans,Tatiana Takiishi,Hannelie Korf,Isabella Spagnuolo,Guido Sebastiani,Karolien Van Huynegem,Lothar Steidler,Silvia Caluwaerts,Pieter Demetter,Clive Wasserfall,Mark A. Atkinson,Francesco Dotta,Pieter Rottiers,Tom Van Belle,Chantal Mathieu +15 more
TL;DR: This treatment stabilized insulitis, preserved functional β-cell mass, and restored normoglycemia in recent-onset NOD mice, even when hyperglycemia was severe at diagnosis, and indicates a great therapeutic potential of orally administered autoantigen-secreting LL for tolerance induction in T1D.