T
Tomáš Etrych
Researcher at Academy of Sciences of the Czech Republic
Publications - 182
Citations - 6549
Tomáš Etrych is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Drug delivery & Drug carrier. The author has an hindex of 42, co-authored 163 publications receiving 5715 citations.
Papers
More filters
Journal ArticleDOI
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties.
TL;DR: In vivo anti-tumor activity of conjugates containing hydrolytically sensitive linkage was also significantly improved in mouse EL4 T cell lymphoma and Cytotoxicity of conjugs was much higher compared with the effect of similar 'classic' conjugate bearing Dox attached via amide bond.
Journal ArticleDOI
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity
Geoffrey M. Lynn,Geoffrey M. Lynn,Richard Laga,Richard Laga,Patricia A. Darrah,Andrew S. Ishizuka,Alexandra J. Balaci,Andrés E Dulcey,Michal Pechar,Robert Pola,Michael Y. Gerner,Ayako Yamamoto,Connor R. Buechler,Kylie M. Quinn,Margery G. Smelkinson,Ondrej Vanek,Ryan Cawood,Thomas Hills,Olga Vasalatiy,Kathrin Kastenmüller,Joseph R. Francica,Lalisa Stutts,Janine K. Tom,Keun Ah Ryu,Aaron P. Esser-Kahn,Tomáš Etrych,Kerry D. Fisher,Leonard W. Seymour,Robert A. Seder +28 more
TL;DR: These findings provide a chemical and structural basis for optimizing adjuvant design to elicit broad-based antibody and T cell responses with protein antigens and are extended to the development of a modular approach that self-assemble into immunogenic particles at physiologic temperatures in vivo.
Journal ArticleDOI
Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin.
Marina Talelli,Maryam Iman,Amir K. Varkouhi,Cristianne J.F. Rijcken,Raymond M. Schiffelers,Tomáš Etrych,Karel Ulbrich,Cornelus F. van Nostrum,Twan Lammers,Twan Lammers,Gert Storm,Wim E. Hennink +11 more
TL;DR: The results presented in this paper show that mPEG-b-p(HPMAm-Lac(n)) polymeric micelles with covalently entrapped doxorubicin is a system highly promising for the targeted delivery of cytostatic agents.
Journal ArticleDOI
HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity.
TL;DR: In this paper, the authors presented data on the synthesis, physicochemical characterisation and in vitro and in vivo biological properties of the new, nontargeted or antibody-targeted polymer-doxorubicin conjugates designed as anticancer drugs.
Journal ArticleDOI
Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy.
TL;DR: The star polymer-Dox conjugates exhibited significantly prolonged blood circulation and enhanced tumor accumulation in tumor-bearing mice, indicating the important role of the EPR effect in its anti-cancer activity.