T
Tomasz Puzyn
Researcher at University of Gdańsk
Publications - 176
Citations - 5737
Tomasz Puzyn is an academic researcher from University of Gdańsk. The author has contributed to research in topics: Quantitative structure–activity relationship & Molecular descriptor. The author has an hindex of 35, co-authored 160 publications receiving 4627 citations. Previous affiliations of Tomasz Puzyn include Gdańsk University of Technology & National Institute for Environmental Studies.
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Journal ArticleDOI
Using nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles
Tomasz Puzyn,Bakhtiyor Rasulev,Agnieszka Gajewicz,Agnieszka Gajewicz,Xiaoke Hu,Thabitha P. Dasari,A. Michalkova,Huey-Min Hwang,Andrey A. Toropov,Danuta Leszczynska,Jerzy Leszczynski +10 more
TL;DR: A model is developed to describe the cytotoxicity of 17 different types of metal oxide nanoparticles to bacteria Escherichia coli that reliably predicts the toxicity of all considered compounds, and the methodology is expected to provide guidance for the future design of safe nanomaterials.
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Toward the development of "nano-QSARs": advances and challenges
TL;DR: It is suggested that, due to high variability in the molecular structures and different mechanisms of toxicity, individual classes of nanoparticles should be modeled separately.
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Advancing risk assessment of engineered nanomaterials: application of computational approaches
Agnieszka Gajewicz,Bakhtiyor Rasulev,Tandabany C. Dinadayalane,Piotr Urbaszek,Tomasz Puzyn,Danuta Leszczynska,Jerzy Leszczynski +6 more
TL;DR: The purpose of this review is to present the current state of knowledge related to the risks of the engineered nanoparticles and to assess the potential of efficient expansion and development of new approaches, which are offered by application of theoretical and computational methods, applicable for evaluation of nanomaterials.
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Zeta Potential for Metal Oxide Nanoparticles: A Predictive Model Developed by a Nano-Quantitative Structure–Property Relationship Approach
Alicja Mikolajczyk,Agnieszka Gajewicz,Bakhtiyor Rasulev,Bakhtiyor Rasulev,Nicole M. Schaeublin,Elisabeth Maurer-Gardner,Saber M. Hussain,Jerzy Leszczynski,Tomasz Puzyn +8 more
TL;DR: In this paper, a quantitative structure-property relationship model (nano-QSPR) was developed to predict the zeta potential of metal oxide nanoparticles using only two descriptors: (i) the spherical size of nanoparticles, a parameter from numerical analysis of transmission electron microscopy (TEM) images, and (ii) the energy of the highest occupied molecular orbital per metal atom.
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Towards understanding mechanisms governing cytotoxicity of metal oxides nanoparticles: hints from nano-QSAR studies.
Agnieszka Gajewicz,Nicole M. Schaeublin,Bakhtiyor Rasulev,Saber M. Hussain,Danuta Leszczynska,Tomasz Puzyn,Jerzy Leszczynski +6 more
TL;DR: The comparison of the toxicity of metal oxide nanoparticles to bacteria Escherichia coli and a human keratinocyte cell line resulted in the hypothesis that different modes of toxic action occur between prokaryotic and eukaryotic systems.