T
Tomoyoshi Kondo
Researcher at Juntendo University
Publications - 71
Citations - 4083
Tomoyoshi Kondo is an academic researcher from Juntendo University. The author has contributed to research in topics: Parkinson's disease & Parkinsonism. The author has an hindex of 31, co-authored 71 publications receiving 3898 citations. Previous affiliations of Tomoyoshi Kondo include Wakayama Medical University.
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Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease.
Makio Mogi,Akifumi Togari,Tomoyoshi Kondo,Yoshikuni Mizuno,Osamu Komure,Sadako Kuno,Hiroshi Ichinose,Toshiharu Nagatsu +7 more
TL;DR: The present data indicate that the lack of neurotrophins, especially BDNF, may be involved in the pathogenesis of PD during progress of neurodegeneration of the nigrostriatal DA neurons.
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Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence.
Shin-ichiro Ikebe,Masashi Tanaka,Kinji Ohno,Wataru Sato,Kazuki Hattori,Tomoyoshi Kondo,Yoshikuni Mizuno,Takayuki Ozawa +7 more
TL;DR: Results indicate that age-related accumulation of deleted mtDNA is accelerated in the parkinsonian striatum and suggest that the deletion contributes to pathophysiological processes underlying Parkinson's disease.
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Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the Parkin gene in affected individuals.
Nobutaka Hattori,Tohru Kitada,Tohru Kitada,Hiroto Matsumine,Shuichi Asakawa,Yasuhiro Yamamura,Hiroyo Yoshino,Tomonori Kobayashi,Masayuki Yokochi,Mei Wang,Asako Yoritaka,Tomoyoshi Kondo,Shigeki Kuzuhara,Shigenobu Nakamura,Nobuyoshi Shimizu,Yoshikuni Mizuno +15 more
TL;DR: The findings indicate that loss of function of the Parkin protein results in the clinical phenotype of AR‐JP and that subregions between introns 2 and 5 of the parkin gene are mutational hot spots.
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Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from parkinsonian brain.
Makio Mogi,Akifumi Togari,Tomoyoshi Kondo,Yoshikuni Mizuno,Osamu Komure,Sadako Kuno,Hiroshi Ichinose,Toshiharu Nagatsu +7 more
TL;DR: The present data suggest the presence of a proapoptotic environment in the substantia nigra of parkinsonian brain, probably inducing vulnerability of neurons and glias towards a variety of noxious factors.
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Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis
TL;DR: The results indicate that phenotype of the mutant mtDNA as Parkinson's disease is expressed when the proportion of deleted mtDNA to normal mtDNA exceeds a threshold of ten times higher value than in the normal subject.