K
Kinji Ohno
Researcher at Nagoya University
Publications - 299
Citations - 13116
Kinji Ohno is an academic researcher from Nagoya University. The author has contributed to research in topics: Acetylcholine receptor & Neuromuscular junction. The author has an hindex of 59, co-authored 270 publications receiving 11463 citations. Previous affiliations of Kinji Ohno include University of Rochester & Juntendo University.
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Journal ArticleDOI
Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson's Disease
Satoru Hasegawa,Sae Goto,Hirokazu Tsuji,Tatsuya Okuno,Takashi Asahara,Koji Nomoto,Akihide Shibata,Yoshiro Fujisawa,Tomomi Minato,Akira Okamoto,Kinji Ohno,Masaaki Hirayama +11 more
TL;DR: The permeability to LPS is likely to be increased without compromising the integrity of intestinal mucosa in PD, and the increased intestinal permeability in PD may make the patients susceptible to intestinal dysbiosis.
Journal ArticleDOI
Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence.
Shin-ichiro Ikebe,Masashi Tanaka,Kinji Ohno,Wataru Sato,Kazuki Hattori,Tomoyoshi Kondo,Yoshikuni Mizuno,Takayuki Ozawa +7 more
TL;DR: Results indicate that age-related accumulation of deleted mtDNA is accelerated in the parkinsonian striatum and suggest that the deletion contributes to pathophysiological processes underlying Parkinson's disease.
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Myofibrillar myopathy: clinical, morphological and genetic studies in 63 patients
TL;DR: MFM is morphologically distinct but genetically heterogeneous, and advances in defining the molecular causes of MFM will probably come from linkage studies of informative kinships or from systematic search for mutations in proteins participating in the intricate network supporting the Z-disk.
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CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study
Manabu Funayama,Kenji Ohe,Kenji Ohe,Taku Amo,Norihiko Furuya,Junji Yamaguchi,Shinji Saiki,Yuanzhe Li,Kotaro Ogaki,Maya Ando,Hiroyo Yoshino,Hiroyuki Tomiyama,Kenya Nishioka,Kazuko Hasegawa,Hidemoto Saiki,Wataru Satake,Kaoru Mogushi,Ryogen Sasaki,Yasumasa Kokubo,Shigeki Kuzuhara,Tatsushi Toda,Yoshikuni Mizuno,Yasuo Uchiyama,Kinji Ohno,Nobutaka Hattori +24 more
TL;DR: CHCHD2 mutations are associated with, and might be a cause of, autosomal dominant Parkinson's disease, and further functional studies are needed to understand how mutant CHCHD 2 might play a part in the pathophysiology of Parkinson's Disease.
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Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity
Steven M. Sine,Kinji Ohno,Cecilia Bouzat,Anthony Auerbach,Margherita Milone,Jerry N. Pruitt,Andrew G. Engel +6 more
TL;DR: In five members of a family and another unrelated person affected by a slow-channel congenital myasthenic syndrome, molecular genetic analysis of acetylcholine receptor (AChR) subunit genes revealed a heterozygous G to A mutation at nucleotide 457 of the alpha subunit, converting codon 153 from glycine to serine (alpha G153S).