T
Toshiro Moroishi
Researcher at Kumamoto University
Publications - 42
Citations - 5206
Toshiro Moroishi is an academic researcher from Kumamoto University. The author has contributed to research in topics: Hippo signaling pathway & Tissue homeostasis. The author has an hindex of 18, co-authored 37 publications receiving 3828 citations. Previous affiliations of Toshiro Moroishi include University of California, San Diego & Kyushu University.
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Journal ArticleDOI
63Glut3 addiction is a druggable vulnerability for a molecularly defined subpopulation of glioblastoma
Erika Cosset,Sten Ilmjärv,Valérie Dutoit,Kathryn C. Elliott,T von Schalscha,Alexander M. Reiss,Maria F. Camargo,Toshiro Moroishi,Laetitia Seguin,German G. Gomez,J S Moo,Olivier Preynat-Seauve,Karl-Heinz Krause,Hervé Chneiweiss,Kun-Liang Guan,Pierre-Yves Dietrich,Sara M. Weis,Paul S. Mischel,David A. Cheresh +18 more
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Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects.
Hiroyuki Shinchi,Fumikazu Komaki,Masaharu Yuki,Haruka Ohara,Naohiro Hayakawa,Masahiro Wakao,Howard B. Cottam,Tomoko Hayashi,Dennis A. Carson,Toshiro Moroishi,Yasuo Suda +10 more
TL;DR: It is indicated that the linker length for immobilizing small-molecule TLR7 ligand on the GNPs significantly affects the adjuvant activity of 1V209-αMan-GNPs and that 1v209- αMan- GNPs immobilized with 1V 209-PEG-23-TA could be superior adjuvants for immunotherapies.
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Glycoholics Anonymous: Cancer Sobers Up with mTORC1
TL;DR: It is revealed that mTORC1 orchestrates the metabolic reprogramming of cancer cells in response to Glycolytic inhibitors, bypassing glycolysis by increasing glutamine uptake and pentose phosphate flux to generate energy and biomass.
Journal ArticleDOI
Publisher Correction: Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
Min Luo,Min Luo,Zhipeng Meng,Zhipeng Meng,Toshiro Moroishi,Toshiro Moroishi,Kimberly C. Lin,Guobo Shen,Fei Mo,Bin Shao,Xiawei Wei,Ping Zhang,Yuquan Wei,Kun-Liang Guan +13 more
TL;DR: A Correction to this paper has been published: https://doi.org/10.1038/s41556-020-00623-4.
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Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis
Haruki Horiguchi,Tsuyoshi Kadomatsu,Shinsei Yumoto,Takeshi Masuda,Keishi Miyata,Shuji Yamamura,Michio Sato,Jun Morinaga,Sumio Ohtsuki,Hideo Baba,Toshiro Moroishi,Yuichi Oike +11 more
TL;DR: The findings suggest that tumor cell-derived ANGPTL2 upregulates expression of OB-cadherin, which then interacts with β-catenin, blocking destruction complex-independent proteasomal degradation of β-Catenin proteins in intestinal tumorigenesis.