Toshiyuki Matsunaga

TL;DR: Accumulating data on the human enzymes provide new insights into their roles in cellular and molecular reactions including xenobiotic metabolism, as well as suggesting their involvement in species-specific biological events and species differences in the metabolism of Xenobiotic carbonyl compounds.

TL;DR: A novel role of AKR1B10 is proposed in controlling isoprenoid homeostasis that is important in cholesterol synthesis and cell proliferation through salvaging isopranoid alcohols, as well as its metabolic regulation by endogenous steroids.

TL;DR: The involvement of up-regulated AKR1C1, AKR 1C3 and proteasome in CDDP resistance of colon cancers and support a chemotherapeutic role for their inhibitors are suggested.

TL;DR: The human aldo–keto reductase AKR1B10 has been recently reported to be significantly up-regulated in some cancer cell lines acquiring resistance toward chemotherapeutic agents, suggesting the validity of the enzyme as a chemoresistance marker.

TL;DR: It is suggested that nuclear distribution of claudin-2 is up-regulated by dephosphorylation and claudIn-2 serves to retain ZONAB and cyclin D1 in the nucleus, resulting in the enhancement of cell proliferation in lung adenocarcinoma cells.