Raymond J. Pickles

TL;DR: Mechanistically, NLRP3 inflammasome activation by the influenza virus was dependent on lysosomal maturation and reactive oxygen species (ROS), and inhibition of ROS induction eliminated IL-1beta production in animals during influenza infection.

TL;DR: Results indicate that CAR is a component of the tight junction and of the functional barrier to paracellular solute movement and thatquestration of CAR in tight junctions may limit virus infection across epithelial surfaces.

TL;DR: Investigation of human primary airway epithelial cell cultures revealed that lumenal columnar cells, specifically ciliated epithelial cells, were targeted by RSV and that cultures became susceptible to infection as they differentiated into a ciliated phenotype, suggesting that RSV infection in the absence of an immune response can be tolerated for >3 months.

TL;DR: It is found that even repeated high doses can only partially correct the CF defect in Cl− transport in vivo and do not correct the Na+ transport defect at all, and indicates that more efficient adenoviral gene-transfer vectors and/or refinement of dosing strategies are needed for therapy of CF lung disease.

TL;DR: An approach that combines existing metagenomics data with reverse genetics to engineer reagents to evaluate emergence and pathogenic potential of circulating zoonotic viruses indicates that the WIV1-coronavirus (CoV) cluster has the ability to directly infect and may undergo limited transmission in human populations.