Ulf Müller-Ladner

TL;DR: Owing to the observation that IL-1 is not only involved in signaling processes resulting in autoimmune and crystal-induced joint destruction but also in several hereditary autoinflammatory syndromes, its value has significantly improved in the past years leading to an enrichment of the current therapeutic armamentarium for the affected patients.

TL;DR: The results show that RAP-PCR combined with cDNA arrays is a suitable method for identifying differentially expressed genes in rheumatoid synovial fibroblasts, using very small amounts of RNA.

TL;DR: Rozymes targeting CL could be a novel and efficient tool to inhibit joint destruction in RA and reduce cartilage destruction in in vitro and in vivo models.

TL;DR: Despite limited evidence for the effectiveness of corticosteroids and immunosuppressive agents in SSc, these potentially harmful drugs are frequently prescribed to patients with all forms of S sc, indicating the need to develop and communicate adequate treatment recommendations.

TL;DR: Examination of rheumatoid arthritis synovial frozen sections of patients with short-term and long-term disease and in situ hybridization and immunohistochemistry indicates that IL-4 STAT is involved in key pathomechanisms in RA synovium and that IL -4 STAT-dependent pathways operate in early and late stages of the disease.