Ulf Müller-Ladner

TL;DR: The present data provide the basis for further investigation of CORS-26 gene regulation in the context of mesenchymal tissue development and in the pathogenesis of bone or skeletal disease.

TL;DR: Although blockade of the CD40–CD40L pathway with BI 655064 in MTX-IR patients with RA resulted in marked changes in clinical and biological parameters, including reductions in activated B-cells, autoantibody production and inflammatory and bone resorption markers, clinical efficacy was not demonstrated in this small phase IIa study.

TL;DR: Terguride treatment did not improve pain, the FIQ score, the TPS score, or the HDS score in the total study population, however, a subgroup of patients with cervical spine stenosis seemed to benefit from tergurid treatment.

TL;DR: The results support the idea that adipokines do not directly influence osteophyte development but the proinflammatory conditions in OA.

TL;DR: The aim of the International von-Behring-Röntgen Symposium was to discuss recent developments in this field, which include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition; and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress.