U
Ursula Horsten
Researcher at RWTH Aachen University
Publications - 8
Citations - 612
Ursula Horsten is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Glycoprotein 130 & Receptor. The author has an hindex of 8, co-authored 8 publications receiving 585 citations.
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Journal Article
Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses
Gerhard Müller-Newen,Andrea Küster,Ulrike Hemmann,Radovan Keul,Ursula Horsten,Astrid Martens,Lutz Graeve,John Wijdenes,Peter C. Heinrich +8 more
TL;DR: SIL-6R of human plasma must be regarded as an antagonistic molecule that enhances the inhibitory activity of sgp130, a promising candidate for the development of IL-6 antagonists.
Journal ArticleDOI
Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions
Heike Dahmen,Ursula Horsten,Andrea Küster,Yannick Jacques,Stephane Minvielle,Ian M. Kerr,Gennaro Ciliberto,Giacomo Paonessa,Peter C. Heinrich,Gerhard Müller-Newen +9 more
TL;DR: The concept that IL-6 and IL-11 activate gp130 by very similar molecular mechanisms is supported, using well-established Jak-deficient cell lines to demonstrate that STAT activation by IL- 11 requires Jak1.
Journal Article
Activation of the Signal Transducer Glycoprotein 130 by Both IL-6 and IL-11 Requires Two Distinct Binding Epitopes
Ingo Kurth,Ursula Horsten,Stefan Pflanz,Heike Dahmen,Andrea Küster,Joachim Grötzinger,Peter C. Heinrich,Gerhard Müller-Newen +7 more
TL;DR: There is a substantial difference in the mechanism of receptor engagement by cytokines that signal via gp130, suggesting a common mode of recognition of helical cytokines by class I cytokine receptors.
Journal ArticleDOI
Molecular Modeling-guided Mutagenesis of the Extracellular Part of gp130 Leads to the Identification of Contact Sites in the Interleukin-6 (IL-6)·IL-6 receptor·gp130 Complex
Ursula Horsten,Gerhard Müller-Newen,Claudia Gerhartz,Axel Wollmer,John Wijdenes,Peter C. Heinrich,Joachim Grötzinger +6 more
TL;DR: The combined approach of molecular modeling and site-directed mutagenesis has led to the identification of amino acid residues in gp130 required for complex formation with IL-6 and its receptor.
Journal ArticleDOI
Importance of the Membrane-Proximal Extracellular Domains for Activation of the Signal Transducer Glycoprotein 130
Ingo Kurth,Ursula Horsten,Stefan Pflanz,Andreas Timmermann,Andrea Küster,Heike Dahmen,Ingrid Tacken,Peter C. Heinrich,Gerhard Müller-Newen +8 more
TL;DR: These findings suggest a functional role of the membrane-proximal domains of gp130 in receptor activation within the hematopoietic receptor family, which critically depends on the architecture of the receptor ectodomain.