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Päivi Marjamäki
Researcher at University of Turku
Publications - 53
Citations - 2244
Päivi Marjamäki is an academic researcher from University of Turku. The author has contributed to research in topics: Receptor & Translocator protein. The author has an hindex of 22, co-authored 52 publications receiving 1883 citations. Previous affiliations of Päivi Marjamäki include Turku University Hospital.
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Journal ArticleDOI
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism
Joni Nikkanen,Saara Forsström,Liliya Euro,Ilse Paetau,Rebecca A. Kohnz,Liya Wang,Dmitri Chilov,Jenni Viinamäki,Anne Roivainen,Päivi Marjamäki,Heidi Liljenbäck,Sofia Ahola,Jana Buzkova,Mügen Terzioglu,Nahid Akhtar Khan,Sini Pirnes-Karhu,Anders Paetau,Tuula Lönnqvist,Antti Sajantila,Pirjo Isohanni,Henna Tyynismaa,Daniel K. Nomura,Brendan J. Battersby,Vidya Velagapudi,Christopher Carroll,Anu Suomalainen +25 more
TL;DR: It is reported that mtDNA replication disorders caused by TWINKLE mutations-mitochondrial myopathy (MM) and infantile onset spinocerebellar ataxia (IOSCA)-remodel cellular dNTP pools in mice are reported and targets for metabolic therapy are offered.
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A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease.
TL;DR: The present findings indicate that nicotinic receptors are affected not only in AD, but also in PD and that dysfunction of the cholinergic system in the frontal cortex is involved in the dementia process in PD.
Journal ArticleDOI
Age-dependent decline in human brain dopamine D1 and D2 receptors
TL;DR: The results show that the dopaminergic system degenerates in the aging striatum and may contribute to the frequent occurrence of extrapyramidal symptoms in the elderly.
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Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions
Saara Forsström,Christopher B. Jackson,Christopher Carroll,Christopher Carroll,Mervi Kuronen,Eija Pirinen,Swagat Pradhan,Anastasiia Marmyleva,Mari Auranen,Iida-Marja Kleine,Nahid Akhtar Khan,Anne Roivainen,Päivi Marjamäki,Heidi Liljenbäck,Liya Wang,Brendan J. Battersby,Uwe Richter,Vidya Velagapudi,Joni Nikkanen,Liliya Euro,Anu Suomalainen,Anu Suomalainen +21 more
TL;DR: The evidence indicates that FGF21 is a local and systemic messenger of mtDNA stress in mice and humans with mitochondrial disease, and drives weight loss and glucose preference, and modifies metabolism and respiratory chain deficiency in a specific hippocampal brain region.
Journal ArticleDOI
Detection of Microglial Activation in an Acute Model of Neuroinflammation Using PET and Radiotracers 11C-(R)-PK11195 and 18F-GE-180
Alex M. Dickens,Susanne Vainio,Päivi Marjamäki,Jarkko Johansson,Paula Lehtiniemi,Johanna Rokka,Juha O. Rinne,Olof Solin,Merja Haaparanta-Solin,Paul A. Jones,William Trigg,Daniel C. Anthony,Laura Airas +12 more
TL;DR: In this paper, a reproducible lipopolysaccharide (LPS)-induced model of acute central nervous system inflammation was used to compare the binding performance of a new translocator protein (TSPO) ligand 18F-GE-180 with 11C-(R)-PK11195.