C
Christopher B. Jackson
Researcher at University of Helsinki
Publications - 39
Citations - 1426
Christopher B. Jackson is an academic researcher from University of Helsinki. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrial disease. The author has an hindex of 17, co-authored 34 publications receiving 935 citations. Previous affiliations of Christopher B. Jackson include MRC Mitochondrial Biology Unit & University of Bern.
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Journal ArticleDOI
mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression
Nahid Akhtar Khan,Joni Nikkanen,Shuichi Yatsuga,Shuichi Yatsuga,Christopher B. Jackson,Liya Wang,Swagat Pradhan,Riikka Kivelä,Alberto Pessia,Vidya Velagapudi,Anu Suomalainen +10 more
TL;DR: The evidence suggests that chronic upregulation of anabolic pathways contributes to MM progression, long-term induction of ISRmt is not protective for muscle, and rapamycin treatment trials should be considered for adult-type MM with raised FGF21.
Journal ArticleDOI
Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions
Saara Forsström,Christopher B. Jackson,Christopher Carroll,Christopher Carroll,Mervi Kuronen,Eija Pirinen,Swagat Pradhan,Anastasiia Marmyleva,Mari Auranen,Iida-Marja Kleine,Nahid Akhtar Khan,Anne Roivainen,Päivi Marjamäki,Heidi Liljenbäck,Liya Wang,Brendan J. Battersby,Uwe Richter,Vidya Velagapudi,Joni Nikkanen,Liliya Euro,Anu Suomalainen,Anu Suomalainen +21 more
TL;DR: The evidence indicates that FGF21 is a local and systemic messenger of mtDNA stress in mice and humans with mitochondrial disease, and drives weight loss and glucose preference, and modifies metabolism and respiratory chain deficiency in a specific hippocampal brain region.
Journal ArticleDOI
Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production.
Poorya Amini,Darko Stojkov,Andrea Felser,Christopher B. Jackson,Carolina Courage,André Schaller,Laurent Gelman,Maria Eugenia Soriano,Jean-Marc Nuoffer,Luca Scorrano,Charaf Benarafa,Shida Yousefi,Hans-Uwe Simon +12 more
TL;DR: A critical role for OPA1 in innate immunity is reported and a detrimental effect on host defense capabilities against pathogen infections is shown.
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3D Co-culture of hiPSC-Derived Cardiomyocytes With Cardiac Fibroblasts Improves Tissue-Like Features of Cardiac Spheroids.
Philippe Beauchamp,Christopher B. Jackson,Lijo Cherian Ozhathil,Irina Agarkova,Cristi L. Galindo,Douglas B. Sawyer,Thomas M. Suter,Christian Zuppinger +7 more
TL;DR: 3D co-culture of hiPSC-CMs and CF is demonstrated to be superior over 2D culture conditions for co- Culture models and more closely mimicking the native state of the myocardium with relevance to drug development as well as for personalized medicine.
Journal ArticleDOI
Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs
Payam A. Gammage,Edoardo Gaude,Lindsey Van Haute,Pedro Rebelo-Guiomar,Pedro Rebelo-Guiomar,Christopher B. Jackson,Joanna Rorbach,Marcin L. Pekalski,Alan J. Robinson,Marine Charpentier,Jean-Paul Concordet,Christian Frezza,Michal Minczuk +12 more
TL;DR: It is concluded that mtZFN-based approaches offer means for mtDNA heteroplasmy manipulation in basic research, and may provide a strategy for therapeutic intervention in selected mitochondrial diseases.