V
V. Samuel Raj
Researcher at SRM University
Publications - 35
Citations - 387
V. Samuel Raj is an academic researcher from SRM University. The author has contributed to research in topics: Mycobacterium tuberculosis & Drug resistance. The author has an hindex of 9, co-authored 35 publications receiving 290 citations. Previous affiliations of V. Samuel Raj include Daiichi Sankyo.
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Journal ArticleDOI
Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections
Alan P. Kozikowski,Oluseye K. Onajole,Oluseye K. Onajole,Jozef Stec,Jozef Stec,Christian Dupont,Albertus Viljoen,Matthias Richard,Tridib Chaira,Tridib Chaira,Shichun Lun,William R. Bishai,V. Samuel Raj,Diane J. Ordway,Laurent Kremer,Laurent Kremer +15 more
TL;DR: The potent activity of a series of indolecarboxamides against M. abscessus infections is reported, introducing a hereto unexploited chemical structure class active against the pathogen with promising translational development possibilities for the treatment of CF patients.
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Ciprofloxacin-resistant Neisseria meningitidis, Delhi, India.
Smita Singhal,Kedar Purnapatre,Vandana Kalia,S. N. Dube,Deepti Nair,Monorama Deb,Pushpa Aggarwal,Sunil Gupta,Dilip J. Upadhyay,Ashok Rattan,V. Samuel Raj +10 more
TL;DR: Results of antimicrobial susceptibility testing of the meningococcal isolates to ciprofloxacin and further sequencing of DNA gyrase A quinolone-resistance–determining region confirmed the emergence of cipROfloxAcin resistance in the outbreak.
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Mode of Action of Ranbezolid against Staphylococci and Structural Modeling Studies of Its Interaction with Ribosomes
Vandana Kalia,Rajni Miglani,Kedar Purnapatre,Tarun Mathur,Smita Singhal,Seema Khan,Voleti Sreedhara Rao,Dilip J. Upadhyay,Kulvinder Singh Saini,Ashok Rattan,V. Samuel Raj +10 more
TL;DR: In vitro translation of the luciferase gene done using bacterial and mammalian ribosomes indicated that ranbezolid specifically inhibited the bacterial ribosome, which clearly helps to elucidate its potent activity against the target pathogen.
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Emergence and Molecular Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates from the Delhi Region in India
Alka Khanna,V. Samuel Raj,Bansidhar Tarai,Ruchi Sood,Pawan Kumar Pareek,Dilip J. Upadhyay,Pawan Sharma,Ashok Rattan,Kulvinder Singh Saini,Harpal Singh +9 more
TL;DR: The data in this report clearly establish the presence of phenotypically distinct XDR strains in India by molecular profiling and further identify specific mutational hot spots within key genes of XDR-TB strains.
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Activity of RBx 11760, a novel biaryl oxazolidinone, against Clostridium difficile
Tarun Mathur,Manoj Kumar,Tarani Kanta Barman,G. Ram Kumar,Vandana Kalia,Smita Singhal,V. Samuel Raj,Dilip J. Upadhyay,Biswajit Das,Pradip Kumar Bhatnagar +9 more
TL;DR: Macromolecular labelling results suggest that RBx 11760 is a potent inhibitor of bacterial protein synthesis, and it could be a promising novel candidate for future drug development against C. difficile infection.