V. Wee Yong

TL;DR: Key papers showing how MR imaging has been combined with a range of animal models to evaluate potential therapeutics for multiple sclerosis are reviewed and advice is given on how to maximize the potential for incorporating MRI into preclinical studies evaluating possible therapeuticals for MS.

TL;DR: The authors showed that acute bouts of exercise in mice profoundly alters the proteome in demyelinating lesions following lysolecithin induced demyeling of the ventral spinal cord, mice were given immediate access to a running wheel for 4 days Lesioned spinal cords and peripheral blood serum were then subjected to tandem mass tag labeling to identify alteration in protein levels.

TL;DR: A focused background on nerve injury and regeneration is presented, the therapeutic use of minocycline in other neurological disorders is considered, and a few relevant comments are made regarding the potential role of mincycline as a therapeutic strategy for nerve repair in the future are presented.

TL;DR: This paper found that about 8% of cells within the human glioblastoma microenvironment coexpreses with brain tumor-initiating cells (BTICs) through not fully understood mechanisms.

TL;DR: The findings show that pSTAT3 does not correlate with inflammatory activity in MS lesions, but that it may play an important role in regulating reactive changes proximal to MS lesions.