V
V. Wee Yong
Researcher at University of Calgary
Publications - 276
Citations - 21024
V. Wee Yong is an academic researcher from University of Calgary. The author has contributed to research in topics: Multiple sclerosis & Microglia. The author has an hindex of 73, co-authored 233 publications receiving 17556 citations. Previous affiliations of V. Wee Yong include Allen Institute for Brain Science & Foothills Medical Centre.
Papers
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Book ChapterDOI
A novel MRI texture analysis of demyelination and inflammation in relapsing-remitting experimental allergic encephalomyelitis
TL;DR: Both high and low frequency signals, representing inflammation and demyelination, were significantly increased in pathological regions compared to normal control tissue, suggesting that this new local spatial-frequency measure of image texture may provide a sensitive and precise indication of disease activity.
Journal ArticleDOI
Microglia in multiple sclerosis: Protectors turn destroyers
TL;DR: The protector-gone-rogue microglia in MS is discussed in this article , where the authors consider mechanisms of microgliosis neurotoxicity and discuss factors, including aging, osteopontin, and iron metabolism, that cause micro-glia to lose their protective states and become injurious.
Journal ArticleDOI
The promise of futility trials in neurological diseases.
Marcus W. Koch,Lawrence Korngut,David G. Patry,Yahya Aghakhani,Chris White,Justyna R. Sarna,Michael Yeung,V. Wee Yong,Daniel Y. C. Heng,Gary Cutter,Luanne M. Metz +10 more
TL;DR: Futility models are discussed, highlighting their advantages as well as challenges to their application in several neurological diseases, including Parkinson disease, stroke and multiple sclerosis.
Journal ArticleDOI
Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis.
James A. Rogers,Manoj Kumar Mishra,Jennifer N. Hahn,Catherine J. Greene,Robin M. Yates,Luanne M. Metz,V. Wee Yong +6 more
TL;DR: G gestational bisphenol-A exposure increases susceptibility to autoimmunity in a mouse model of multiple sclerosis; the disease manifested in adult male, but not female, mice when a suboptimal insult was applied.
Journal ArticleDOI
Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon.
Franz J. Zemp,Franz J. Zemp,Brienne A. McKenzie,Brienne A. McKenzie,Xueqing Lun,Xueqing Lun,Lori Maxwell,Lori Maxwell,Karlyne M. Reilly,Grant McFadden,V. Wee Yong,Peter A. Forsyth,Peter A. Forsyth,Peter A. Forsyth +13 more
TL;DR: These syngeneic cell lines are relevant preclinical models for testing experimental glioma treatments, and it is shown that IFNα/β is not responsible for the MYXV treatment resistance seen in syngenesic gliomas models.