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V. Wee Yong

Researcher at University of Calgary

Publications -  276
Citations -  21024

V. Wee Yong is an academic researcher from University of Calgary. The author has contributed to research in topics: Multiple sclerosis & Microglia. The author has an hindex of 73, co-authored 233 publications receiving 17556 citations. Previous affiliations of V. Wee Yong include Allen Institute for Brain Science & Foothills Medical Centre.

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Journal ArticleDOI

Interferon beta in the treatment of multiple sclerosis Mechanisms of action

V. Wee Yong, +3 more
- 01 Sep 1998 - 
TL;DR: In this review, several biological activities of IFN-β are highlighted, including its inhibitory effects on proliferation of leukocytes and antigen presentation, and these activities are likely to act in concert to account for the mechanism of IFn-β in MS.
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Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis

Amit Bar-Or, +9 more
- 01 Dec 2003 - 
TL;DR: Monocytes are prominent contributors of the neuroinflammation in multiple sclerosis through a mechanism that involves their high MMP expression and that they identify specific MMP members as targets for novel therapeutics in the disease.
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Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury

Steven Casha, +5 more
- 01 Apr 2012 - 
TL;DR: The minocycline regimen established in this study proved feasible, safe and was associated with a tendency towards improvement across several outcome measures, which are encouraging and warrant further investigation in a multi-centre phase III trial.
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A1 Adenosine Receptor Upregulation and Activation Attenuates Neuroinflammation and Demyelination in a Model of Multiple Sclerosis

Shigeki Tsutsui, +7 more
- 11 Feb 2004 - 
TL;DR: Modulation of neuroinflammation by the A1AR represents a novel mechanism that provides new therapeutic opportunities for MS and other demyelinating diseases.
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Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes

Luke Y. S. Oh, +6 more
- 01 Oct 1999 - 
TL;DR: Genetic evidence that MMP-9 facilitates process outgrowth by OLs in vivo and in culture is provided, indicating a requirement for M MP-9 in process out growth.