V. Wee Yong

TL;DR: The results suggest that CaMKII-mediated pathways prevent TRAIL-induced apoptosis in human astrocytes under conditions in which TRAIL death receptors are upregulated.

TL;DR: It is found that IL-33 expression in a large subset of human glioma specimens and murine models correlates with increased tumor-associated macrophages/monocytes/microglia, which supports the paradigm that recruitment and activation of immune cells, when instructed appropriately, offer a therapeutic strategy that switches the focus from the cancer cell alone to one that includes the normal host environment.

TL;DR: How immune checkpoints drive exhaustion in T cells while favoring tumor metabolism, and how glucose competition in the unique CNS milieu is an important consideration to improve the outcomes of immune checkpoint blockade in glioblastoma are reviewed.

TL;DR: In vivo and at asymptomatic stages following intracerebral implant of cells, mice harboring MT2-MMP siRNA downregulated clones had smaller and less invasive tumors compared with mice implanted with non-specific siRNA control cells.

TL;DR: In most disorders, it remains uncertain whether inflammation and protein aggregation are neurotoxic or neuroprotective, so elucidating the mechanisms that orchestrate neuronal diseases should facilitate development of neuroProtective and neurorestorative strategies.