V
V. Wee Yong
Researcher at University of Calgary
Publications - 276
Citations - 21024
V. Wee Yong is an academic researcher from University of Calgary. The author has contributed to research in topics: Multiple sclerosis & Microglia. The author has an hindex of 73, co-authored 233 publications receiving 17556 citations. Previous affiliations of V. Wee Yong include Allen Institute for Brain Science & Foothills Medical Centre.
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Journal ArticleDOI
Changes in tissue directionality reflect differences in myelin content after demyelination in mice spinal cords
TL;DR: The findings suggest that greater myelin integrity is associated with better tissue anisotropy, independent of injury location, and this may help understand disease mechanisms and development in MS and other demyelinating disorders.
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Evaluating Soluble EMMPRIN as a Marker of Disease Activity in Multiple Sclerosis: Studies of Serum and Cerebrospinal Fluid
Deepak Kumar Kaushik,Heather Y. F. Yong,Jennifer N. Hahn,Claudia Silva,Steven Casha,R. John Hurlbert,Francois H. Jacques,Robert P. Lisak,Omar Khan,Carolina Ionete,Catherine Larochelle,Alex Prat,Amit Bar-Or,V. Wee Yong +13 more
TL;DR: It is reported that activated T-cells can secrete soluble form of EMMPRIN (sEMMPRIN) upon activation and the differential expression of sEMM PRIN in the CSF of primary and secondary progressive MS invites hypotheses of the still undefined roles of E MMPRin in the CNS.
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Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes.
Susobhan Sarkar,Yibo Li,Reza Mirzaei,Khalil S. Rawji,Candice C. Poon,Jianxiong Wang,Mehul Kumar,Pinaki Bose,V. Wee Yong +8 more
TL;DR: Demeclocycline is a candidate to reactivate compromised immune cells to improve the prognosis of patients with gliomas and is identified as a novel inhibitor of the growth of BTICs, through direct effect and through indirect stimulation of monocytes.
Journal ArticleDOI
Quantitative analysis of spinal cord neuropathology in experimental autoimmune encephalomyelitis.
TL;DR: A quantitative whole slide imaging immunofluorescence method that allows longitudinal sections of the entire EAE thoracic spinal cord to be investigated for the extent of neuroinflammation, axonal loss, and myelin density is described in this article.