M
Miho Nozaki
Researcher at Nagoya City University
Publications - 78
Citations - 4365
Miho Nozaki is an academic researcher from Nagoya City University. The author has contributed to research in topics: Choroidal neovascularization & Macular degeneration. The author has an hindex of 23, co-authored 73 publications receiving 3960 citations. Previous affiliations of Miho Nozaki include University of Kentucky.
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Journal ArticleDOI
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
Mark E. Kleinman,Kiyoshi Yamada,Atsunobu Takeda,Vasu Chandrasekaran,Miho Nozaki,Judit Z. Baffi,Romulo Albuquerque,S. Yamasaki,M. Itaya,Yuzhen Pan,Binoy Appukuttan,Daniel Gibbs,Zhenglin Yang,Katalin Karikó,Balamurali K. Ambati,Balamurali K. Ambati,Traci A. Wilgus,Luisa A. DiPietro,Eiji Sakurai,Kang Zhang,Justine R. Smith,Ethan Will Taylor,Jayakrishna Ambati +22 more
TL;DR: It is shown that generic siRNAs might treat angiogenic disorders that affect 8% of the world’s population, and that si RNAs might induce unanticipated vascular or immune effects.
Journal ArticleDOI
Corneal avascularity is due to soluble VEGF receptor-1
Balamurali K. Ambati,Miho Nozaki,Nirbhai Singh,Atsunobu Takeda,P. Jani,Tushar Suthar,Romulo Albuquerque,Elizabeth Richter,Eiji Sakurai,Eiji Sakurai,Michael T. Newcomb,Mark E. Kleinman,Ruth B. Caldwell,Qing Lin,Yuichiro Ogura,Angela Orecchia,Don Samuelson,Dalen W. Agnew,Dalen W. Agnew,Judy St. Leger,W. Richard Green,Parameshwar J. Mahasreshti,David T. Curiel,Donna Kwan,Helene Marsh,Sakae Ikeda,Lucy J. Leiper,J. Martin Collinson,Sasha Bogdanovich,Tejvir S. Khurana,Masabumi Shibuya,Megan Baldwin,Napoleone Ferrara,Hans-Peter Gerber,Sandro De Falco,Jassir Witta,Judit Z. Baffi,B.J. Raisler,Jayakrishna Ambati +38 more
TL;DR: This paper showed that the cornea expresses soluble VEGF receptor-1 (sVEGFR-1; also known as sflt-1) and that suppression of this endogenous VEGGF-A trap by neutralizing antibodies, RNA interference or Cre-lox-mediated gene disruption abolishes corneal avascularity in mice.
Journal ArticleDOI
Drusen complement components C3a and C5a promote choroidal neovascularization
Miho Nozaki,B.J. Raisler,Eiji Sakurai,J. Vidya Sarma,Scott R. Barnum,John D. Lambris,Yali Chen,Kang Zhang,Balamurali K. Ambati,Judit Z. Baffi,Jayakrishna Ambati +10 more
TL;DR: It is demonstrated that C3a and C5a are generated early in the course of laser-induced CNV, an accelerated model of neovascular AMD driven by VEGF and recruitment of leukocytes into the choroid, and that genetic ablation of receptors for C1a or C2a reduces VEGf expression, leukocyte recruitment, and CNV formation after laser injury.
Journal ArticleDOI
Enlargement of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography.
TL;DR: The data suggest that diabetic eyes show retinal microcirculation impairment in the macula even before retinopathy develops, suggesting that en face OCTA is a useful noninvasive screening tool for detecting early microcirculatory disturbance in patients with diabetes.